tert-butyl N-[(1R,2S)-1-benzyl-3-[(4R)-7-fluoro-4-methyl-1,1-dioxo-1,3,4,5-tetrahydro-2H-1λ6,2-benzothiazepin-2-yl]-2-hydroxypropyl]carbamate

Base Information

Chemical Name:tert-butyl N-[(1R,2S)-1-benzyl-3-[(4R)-7-fluoro-4-methyl-1,1-dioxo-1,3,4,5-tetrahydro-2H-1λ6,2-benzothiazepin-2-yl]-2-hydroxypropyl]carbamate
CAS No.:1301767-93-0
Molecular Formula:C₂₅H₃₃FN₂O₅S
Molecular Weight:492.612
Hs Code.:

tert-butyl N-[(1R,2S)-1-benzyl-3-[(4R)-7-fluoro-4-methyl-1,1-dioxo-1,3,4,5-tetrahydro-2H-1λ6,2-benzothiazepin-2-yl]-2-hydroxypropyl]carbamate

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Chemical Property of tert-butyl N-[(1R,2S)-1-benzyl-3-[(4R)-7-fluoro-4-methyl-1,1-dioxo-1,3,4,5-tetrahydro-2H-1λ6,2-benzothiazepin-2-yl]-2-hydroxypropyl]carbamate

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Technology Process of tert-butyl N-[(1R,2S)-1-benzyl-3-[(4R)-7-fluoro-4-methyl-1,1-dioxo-1,3,4,5-tetrahydro-2H-1λ6,2-benzothiazepin-2-yl]-2-hydroxypropyl]carbamate

There total 6 articles about tert-butyl N-[(1R,2S)-1-benzyl-3-[(4R)-7-fluoro-4-methyl-1,1-dioxo-1,3,4,5-tetrahydro-2H-1λ6,2-benzothiazepin-2-yl]-2-hydroxypropyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 1301767-93-0
tert-butyl N-[(1R,2S)-1-benzyl-3-[(4R)-7-fluoro-4-methyl-1,1-dioxo-1,3,4,5-tetrahydro-2H-1λ6,2-benzothiazepin-2-yl]-2-hydroxypropyl]carbamate

Guidance literature:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1309607-12-2
C₂₀H₂₅FN₂O₃S

: 1301767-93-0
tert-butyl N-[(1R,2S)-1-benzyl-3-[(4R)-7-fluoro-4-methyl-1,1-dioxo-1,3,4,5-tetrahydro-2H-1λ6,2-benzothiazepin-2-yl]-2-hydroxypropyl]carbamate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; Cooling with ice; Inert atmosphere;
DOI:10.1021/jm200778q

Reference yield:

: 351003-45-7
2-bromo-4-fluorobenzene-1-sulfonyl chloride

: 1301767-93-0
tert-butyl N-[(1R,2S)-1-benzyl-3-[(4R)-7-fluoro-4-methyl-1,1-dioxo-1,3,4,5-tetrahydro-2H-1λ6,2-benzothiazepin-2-yl]-2-hydroxypropyl]carbamate

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine / 20 °C / Inert atmosphere

2: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / toluene / 60 - 110 °C / Inert atmosphere

3: caesium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

4: trifluoroacetic acid / dichloromethane / 20 °C / Inert atmosphere

5: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C / Cooling with ice; Inert atmosphere

With pyridine; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; caesium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm200778q