(-)-2-(2-(2-((2R,4S)-2-(tert-butyldiphenylsilyloxy)ethyl)-4-(triisopropylsilyloxy)-3,4-dihydro-2H-pyran-6-yl)-5-(trifluoromethyl)phenyl)ethanol

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Chemical Name:(-)-2-(2-(2-((2R,4S)-2-(tert-butyldiphenylsilyloxy)ethyl)-4-(triisopropylsilyloxy)-3,4-dihydro-2H-pyran-6-yl)-5-(trifluoromethyl)phenyl)ethanol
CAS No.:1308314-52-4
Molecular Formula:C₄₁H₅₇F₃O₄Si₂
Molecular Weight:727.067
Hs Code.:

(-)-2-(2-(2-((2R,4S)-2-(tert-butyldiphenylsilyloxy)ethyl)-4-(triisopropylsilyloxy)-3,4-dihydro-2H-pyran-6-yl)-5-(trifluoromethyl)phenyl)ethanol

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Chemical Property of (-)-2-(2-(2-((2R,4S)-2-(tert-butyldiphenylsilyloxy)ethyl)-4-(triisopropylsilyloxy)-3,4-dihydro-2H-pyran-6-yl)-5-(trifluoromethyl)phenyl)ethanol

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Technology Process of (-)-2-(2-(2-((2R,4S)-2-(tert-butyldiphenylsilyloxy)ethyl)-4-(triisopropylsilyloxy)-3,4-dihydro-2H-pyran-6-yl)-5-(trifluoromethyl)phenyl)ethanol

There total 8 articles about (-)-2-(2-(2-((2R,4S)-2-(tert-butyldiphenylsilyloxy)ethyl)-4-(triisopropylsilyloxy)-3,4-dihydro-2H-pyran-6-yl)-5-(trifluoromethyl)phenyl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (-)-(2R,4S)-2-[2-(tert-butyldiphenylsiloxy)ethyl]-6-(tributylstannyl)-4-(triisopropylsilyloxy)-3,4-dihydro-2H-pyran

: 1308314-52-4
(-)-2-(2-(2-((2R,4S)-2-(tert-butyldiphenylsilyloxy)ethyl)-4-(triisopropylsilyloxy)-3,4-dihydro-2H-pyran-6-yl)-5-(trifluoromethyl)phenyl)ethanol

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / Reflux; Darkness; Inert atmosphere

2: methanol; potassium carbonate / tetrahydrofuran

With methanol; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In tetrahydrofuran; toluene; 1: Stille coupling;
DOI:10.1021/ja201249c

Reference yield:

: 869725-53-1
(2-bromo-5-(trifluoromethyl)phenyl)methanol

: 1308314-52-4
(-)-2-(2-(2-((2R,4S)-2-(tert-butyldiphenylsilyloxy)ethyl)-4-(triisopropylsilyloxy)-3,4-dihydro-2H-pyran-6-yl)-5-(trifluoromethyl)phenyl)ethanol

Guidance literature:: Multi-step reaction with 7 steps

1.1: Dess-Martin periodane / dichloromethane / 1 h / 20 °C / Inert atmosphere

2.1: potassium hexamethylsilazane / toluene / 1 h / 0 - 20 °C / Inert atmosphere

2.2: 7 h / 0 - 20 °C / Inert atmosphere

3.1: hydrogenchloride / tetrahydrofuran; water / 12 h / Reflux

4.1: sodium tetrahydroborate / methanol / 0 - 20 °C / Inert atmosphere

5.1: dmap; triethylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere

6.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / Reflux; Darkness; Inert atmosphere

7.1: methanol; potassium carbonate / tetrahydrofuran

With hydrogenchloride; methanol; dmap; sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium hexamethylsilazane; potassium carbonate; Dess-Martin periodane; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water; toluene; 6.1: Stille coupling;
DOI:10.1021/ja201249c