1'-neopentyl-4-fluoro-1-[2-({5-[4-(trifluoromethoxy)phenyl]-1,3,4-thiadiazol-2-yl}amino)phenyl]-1,2-dihydrospiro[indole-3,4'-piperidine]-7-ol

Base Information

Chemical Name:1'-neopentyl-4-fluoro-1-[2-({5-[4-(trifluoromethoxy)phenyl]-1,3,4-thiadiazol-2-yl}amino)phenyl]-1,2-dihydrospiro[indole-3,4'-piperidine]-7-ol
CAS No.:1554015-14-3
Molecular Formula:C₃₂H₃₃F₄N₅O₂S
Molecular Weight:627.706
Hs Code.:

1'-neopentyl-4-fluoro-1-[2-({5-[4-(trifluoromethoxy)phenyl]-1,3,4-thiadiazol-2-yl}amino)phenyl]-1,2-dihydrospiro[indole-3,4'-piperidine]-7-ol

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Chemical Property of 1'-neopentyl-4-fluoro-1-[2-({5-[4-(trifluoromethoxy)phenyl]-1,3,4-thiadiazol-2-yl}amino)phenyl]-1,2-dihydrospiro[indole-3,4'-piperidine]-7-ol

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Technology Process of 1'-neopentyl-4-fluoro-1-[2-({5-[4-(trifluoromethoxy)phenyl]-1,3,4-thiadiazol-2-yl}amino)phenyl]-1,2-dihydrospiro[indole-3,4'-piperidine]-7-ol

There total 3 articles about 1'-neopentyl-4-fluoro-1-[2-({5-[4-(trifluoromethoxy)phenyl]-1,3,4-thiadiazol-2-yl}amino)phenyl]-1,2-dihydrospiro[indole-3,4'-piperidine]-7-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1609548-39-1
C₃₃H₃₅F₄N₅O₂S

: 1554015-14-3
1'-neopentyl-4-fluoro-1-[2-({5-[4-(trifluoromethoxy)phenyl]-1,3,4-thiadiazol-2-yl}amino)phenyl]-1,2-dihydrospiro[indole-3,4'-piperidine]-7-ol

Guidance literature:: With boron trichloride; tetra-(n-butyl)ammonium iodide; In dichloromethane; at -50 - 20 ℃; for 16h;
DOI:10.1016/j.bmcl.2014.04.011

Reference yield:

: 1609548-36-8
C₂₅H₃₀FN₃OS

: 1554015-14-3
1'-neopentyl-4-fluoro-1-[2-({5-[4-(trifluoromethoxy)phenyl]-1,3,4-thiadiazol-2-yl}amino)phenyl]-1,2-dihydrospiro[indole-3,4'-piperidine]-7-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: dichloromethane / 16 h / 20 °C

1.2: 0.5 h / 20 °C

2.1: boron trichloride; tetra-(n-butyl)ammonium iodide / dichloromethane / 16 h / -50 - 20 °C

With boron trichloride; tetra-(n-butyl)ammonium iodide; In dichloromethane;
DOI:10.1016/j.bmcl.2014.04.011

Reference yield:

: 1609548-35-7
C₂₄H₃₂FN₃O

: 1554015-14-3
1'-neopentyl-4-fluoro-1-[2-({5-[4-(trifluoromethoxy)phenyl]-1,3,4-thiadiazol-2-yl}amino)phenyl]-1,2-dihydrospiro[indole-3,4'-piperidine]-7-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: dichloromethane / 5 h / 20 °C

2.1: dichloromethane / 16 h / 20 °C

2.2: 0.5 h / 20 °C

3.1: boron trichloride; tetra-(n-butyl)ammonium iodide / dichloromethane / 16 h / -50 - 20 °C

With boron trichloride; tetra-(n-butyl)ammonium iodide; In dichloromethane;
DOI:10.1016/j.bmcl.2014.04.011