Technology Process of (R)-benzyl 2-(4-methoxyphenoxy)propionate
There total 3 articles about (R)-benzyl 2-(4-methoxyphenoxy)propionate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
copper(I) triflate benzene complex; (3R,9aS)-2-phenyl-3-[2-(di(tert-butyl)phosphino)phenyl]-2,3,9,9a-tetrahydro-1H-imidazo[1,5-a]indole-1-one;
In
dichloromethane;
at 0 ℃;
for 6h;
optical yield given as %ee;
DOI:10.1021/ol202977j
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydride / tetrahydrofuran / 3 h / 20 °C
1.2: 12 h / 80 °C
2.1: 4-acetamidobenzenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 12 h / 20 °C
3.1: copper(I) triflate benzene complex; (3R,9aS)-2-phenyl-3-[2-(di(tert-butyl)phosphino)phenyl]-2,3,9,9a-tetrahydro-1H-imidazo[1,5-a]indole-1-one / dichloromethane / 6 h / 0 °C
With
copper(I) triflate benzene complex; (3R,9aS)-2-phenyl-3-[2-(di(tert-butyl)phosphino)phenyl]-2,3,9,9a-tetrahydro-1H-imidazo[1,5-a]indole-1-one; 4-acetamidobenzenesulfonyl azide; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene;
In
tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/ol202977j
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 4-acetamidobenzenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 12 h / 20 °C
2: copper(I) triflate benzene complex; (3R,9aS)-2-phenyl-3-[2-(di(tert-butyl)phosphino)phenyl]-2,3,9,9a-tetrahydro-1H-imidazo[1,5-a]indole-1-one / dichloromethane / 6 h / 0 °C
With
copper(I) triflate benzene complex; (3R,9aS)-2-phenyl-3-[2-(di(tert-butyl)phosphino)phenyl]-2,3,9,9a-tetrahydro-1H-imidazo[1,5-a]indole-1-one; 4-acetamidobenzenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene;
In
dichloromethane; acetonitrile;
DOI:10.1021/ol202977j