7-{2-[(Z)-Methoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-8-oxo-5,6,7,8-tetrahydro-3H-pyrazolo[1,2-a]pyridazine-1,2-dicarboxylic acid diallyl ester

Base Information

• Chemical Name: 7-{2-[(Z)-Methoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-8-oxo-5,6,7,8-tetrahydro-3H-pyrazolo[1,2-a]pyridazine-1,2-dicarboxylic acid diallyl ester
• CAS No.: 133627-80-2
• Molecular Formula: C₄₀H₃₈N₆O₇S
• Molecular Weight: 746.844
• Mol file: 133627-80-2.mol

Synonyms:

Chemical Property of 7-{2-[(Z)-Methoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-8-oxo-5,6,7,8-tetrahydro-3H-pyrazolo[1,2-a]pyridazine-1,2-dicarboxylic acid diallyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-{2-[(Z)-Methoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-8-oxo-5,6,7,8-tetrahydro-3H-pyrazolo[1,2-a]pyridazine-1,2-dicarboxylic acid diallyl ester

There total 3 articles about 7-{2-[(Z)-Methoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-8-oxo-5,6,7,8-tetrahydro-3H-pyrazolo[1,2-a]pyridazine-1,2-dicarboxylic acid diallyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C10H17N3O3 → 7-{2-[(Z)-Methoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-8-oxo-5,6,7,8-tetrahydro-3H-pyrazolo[1,2-a]pyridazine-1,2-dicarboxylic acid diallyl ester (133627-80-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 1,2-dichloro-ethane / 4 h / Heating

2: 3 N HCl(g), glacial acetic acid / 0.08 h

3: N-methylmorpholine / 1.) 0 deg C, 1 h, 2.) RT, 2 h

With 4-methyl-morpholine; hydrogenchloride; acetic acid; In 1,2-dichloro-ethane;

DOI:10.1021/jm00109a030

Reference yield:

2-(2-aminothiazol-4-yl)-2-(methoxy)iminoacetic acid (64485-90-1) → 7-{2-[(Z)-Methoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-8-oxo-5,6,7,8-tetrahydro-3H-pyrazolo[1,2-a]pyridazine-1,2-dicarboxylic acid diallyl ester (133627-80-2)

Guidance literature:

Multi-step reaction with 2 steps

1: POCl₃, N-methylmorpholine / CH₂Cl₂ / 0.5 h / 0 °C

2: N-methylmorpholine / 1.) 0 deg C, 1 h, 2.) RT, 2 h

With 4-methyl-morpholine; trichlorophosphate; In dichloromethane;

DOI:10.1021/jm00109a030

Reference yield:

7-tert-Butoxycarbonylamino-8-oxo-5,6,7,8-tetrahydro-3H-pyrazolo[1,2-a]pyridazine-1,2-dicarboxylic acid diallyl ester (133627-79-9) → 7-{2-[(Z)-Methoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-8-oxo-5,6,7,8-tetrahydro-3H-pyrazolo[1,2-a]pyridazine-1,2-dicarboxylic acid diallyl ester (133627-80-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 3 N HCl(g), glacial acetic acid / 0.08 h

2: N-methylmorpholine / 1.) 0 deg C, 1 h, 2.) RT, 2 h

With 4-methyl-morpholine; hydrogenchloride; acetic acid;

DOI:10.1021/jm00109a030

upstream raw materials:

7-tert-Butoxycarbonylamino-8-oxo-5,6,7,8-tetrahydro-3H-pyrazolo[1,2-a]pyridazine-1,2-dicarboxylic acid diallyl ester

2-(2-aminothiazol-4-yl)-2-(methoxy)iminoacetic acid