(1S,2R,3S,4S,5R,6R)-2-amino-3-[(3,4-dichlorophenyl)-sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid hydrochloride

Base Information

Chemical Name:(1S,2R,3S,4S,5R,6R)-2-amino-3-[(3,4-dichlorophenyl)-sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid hydrochloride
CAS No.:1377615-47-8
Molecular Formula:C₁₅H₁₅Cl₂NO₅S*ClH
Molecular Weight:428.721
Hs Code.:

(1S,2R,3S,4S,5R,6R)-2-amino-3-[(3,4-dichlorophenyl)-sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid hydrochloride

Synonyms:

Suppliers and Price of (1S,2R,3S,4S,5R,6R)-2-amino-3-[(3,4-dichlorophenyl)-sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1S,2R,3S,4S,5R,6R)-2-amino-3-[(3,4-dichlorophenyl)-sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1S,2R,3S,4S,5R,6R)-2-amino-3-[(3,4-dichlorophenyl)-sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid hydrochloride

There total 6 articles about (1S,2R,3S,4S,5R,6R)-2-amino-3-[(3,4-dichlorophenyl)-sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1377615-47-8
(1S,2R,3S,4S,5R,6R)-2-amino-3-[(3,4-dichlorophenyl)-sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid hydrochloride

Guidance literature:

Reference yield:

: 1377615-85-4
di-tert-butyl (1S,2R,3S,4S,5R,6R)-2-(tert-butoxycarbonylamino)-3-[(3,4-dichlorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]-hexane-2,6-dicarboxylate

: 1377615-47-8
(1S,2R,3S,4S,5R,6R)-2-amino-3-[(3,4-dichlorophenyl)-sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 70 ℃; for 2h;
DOI:10.1021/acs.jmedchem.6b01119

Reference yield:

: 1377615-79-6
di-tert-butyl (1S,2R,5R,6R)-2-(tert-butoxycarbonylamino)-3-(dimethylaminomethylene)-4-oxo-bicyclo[3.1.0]hexane-2,6-dicarboxylate

: 1377615-47-8
(1S,2R,3S,4S,5R,6R)-2-amino-3-[(3,4-dichlorophenyl)-sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine; diisobutylaluminium hydride / toluene; tetrahydrofuran / 3 h / -78 °C

2: triethylamine / diethyl ether / 2 h / Heating

3: dimethylsulfide borane complex; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole / tetrahydrofuran; diethyl ether / 1.17 h / -10 - 20 °C

4: hydrogenchloride / 1,4-dioxane / 2 h / 70 °C

With hydrogenchloride; dimethylsulfide borane complex; diisobutylaluminium hydride; triethylamine; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; 1,4-dioxane; diethyl ether; toluene; 2: |Michael Addition;
DOI:10.1021/acs.jmedchem.6b01119