3-(4-methylphenyl)-2-{[2-(4-chlorophenyl)-2-oxoethyl]sulfanyl}-5,6-dihydrospiro(benzo[h]quinazoline-5,1'-cyclohexane)-4(3H)-one

Base Information

Chemical Name:3-(4-methylphenyl)-2-{[2-(4-chlorophenyl)-2-oxoethyl]sulfanyl}-5,6-dihydrospiro(benzo[h]quinazoline-5,1'-cyclohexane)-4(3H)-one
CAS No.:354551-67-0
Molecular Formula:C₃₂H₂₉ClN₂O₂S
Molecular Weight:541.113
Hs Code.:
Mol file:354551-67-0.mol

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Chemical Property of 3-(4-methylphenyl)-2-{[2-(4-chlorophenyl)-2-oxoethyl]sulfanyl}-5,6-dihydrospiro(benzo[h]quinazoline-5,1'-cyclohexane)-4(3H)-one

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Technology Process of 3-(4-methylphenyl)-2-{[2-(4-chlorophenyl)-2-oxoethyl]sulfanyl}-5,6-dihydrospiro(benzo[h]quinazoline-5,1'-cyclohexane)-4(3H)-one

There total 3 articles about 3-(4-methylphenyl)-2-{[2-(4-chlorophenyl)-2-oxoethyl]sulfanyl}-5,6-dihydrospiro(benzo[h]quinazoline-5,1'-cyclohexane)-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 286000-46-2
4-oxo-2-thioxo-3-p-tolyl-1,2,3,4,5,6-hexahydrospiro(benzo[h]quinazoline-5,1'-cyclohexane)

: 354551-67-0
C₃₂H₂₉ClN₂O₂S

Guidance literature:: With potassium hydroxide; In ethanol; for 8h; Heating;
DOI:10.1007/BF02251821

Reference yield:

: 622-59-3
1-isothiocyanato-4-methylbenzene

: 354551-67-0
C₃₂H₂₉ClN₂O₂S

Guidance literature:: Multi-step reaction with 2 steps

1.1: ethanol / Heating

1.2: 81 percent / KOH / aq. ethanol / Heating

2.1: 63 percent / KOH / ethanol / 8 h / Heating

With potassium hydroxide; In ethanol; 1.1: Addition / 1.2: Cyclization / 2.1: Alkylation;
DOI:10.1007/BF02251821

Reference yield:

: 4-amino-3-ethoxycarbonyl-1,2-dihydrospiro[naphthalene-2,1'-cyclohexane]

: 354551-67-0
C₃₂H₂₉ClN₂O₂S

Guidance literature:: Multi-step reaction with 2 steps

1.1: ethanol / Heating

1.2: 81 percent / KOH / aq. ethanol / Heating

2.1: 63 percent / KOH / ethanol / 8 h / Heating

With potassium hydroxide; In ethanol; 1.1: Addition / 1.2: Cyclization / 2.1: Alkylation;
DOI:10.1007/BF02251821