Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-pyren-1-yl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester methyl ester

Base Information

• Chemical Name: Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-pyren-1-yl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester methyl ester
• CAS No.: 115494-43-4
• Molecular Formula: C₄₈H₅₂N₃O₈P
• Molecular Weight: 829.93
• Mol file: 115494-43-4.mol

Synonyms:

Chemical Property of Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-pyren-1-yl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-pyren-1-yl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester methyl ester

There total 5 articles about Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-pyren-1-yl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

pyrene-1-aldehyde (3029-19-4) → Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-pyren-1-yl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester methyl ester (115494-43-4)

Guidance literature:

Multi-step reaction with 5 steps

1: KCN, MnO₂

3: 76 percent / acetyl chloride / cyclohexane / 0.17 h / Heating

4: 67 percent / pyridine / 1 h / 0 °C

With potassium cyanide; manganese(IV) oxide; acetyl chloride; In pyridine; cyclohexane;

DOI:10.1016/S0040-4039(00)95616-8

Reference yield:

1-pyrenecarboxylic acid methyl ester (6145-35-3) → Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-pyren-1-yl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester methyl ester (115494-43-4)

Guidance literature:

Multi-step reaction with 4 steps

2: 76 percent / acetyl chloride / cyclohexane / 0.17 h / Heating

3: 67 percent / pyridine / 1 h / 0 °C

With acetyl chloride; In pyridine; cyclohexane;

DOI:10.1016/S0040-4039(00)95616-8

Reference yield:

Bis-(4-methoxy-phenyl)-pyren-1-yl-methanol (114591-59-2) → Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-pyren-1-yl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester methyl ester (115494-43-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 76 percent / acetyl chloride / cyclohexane / 0.17 h / Heating

2: 67 percent / pyridine / 1 h / 0 °C

With acetyl chloride; In pyridine; cyclohexane;

DOI:10.1016/S0040-4039(00)95616-8

upstream raw materials:

1-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-pyren-1-yl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione

pyrene-1-aldehyde

1-pyrenecarboxylic acid methyl ester

1,1-bis-(4-methoxyphenyl)-1'-pyrenyl-methyl-chloride