VT-464 (raceMate)

Base Information

• Chemical Name: VT-464 (raceMate)
• CAS No.: 1375603-36-3
• Molecular Formula: C₁₈H₁₇F₄N₃O₃
• Molecular Weight: 399.345
• Mol file: 1375603-36-3.mol

Synonyms:

Chemical Property of VT-464 (raceMate)

Chemical Property:

• Boiling Point: 536.3±45.0 °C(Predicted)
• PKA: 8.69±0.70(Predicted)
• Density: 1.393±0.06 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

VT-464racemate 98+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of VT-464 (raceMate)

There total 5 articles about VT-464 (raceMate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

C24H31F4N3O4Si (1375603-92-1) → 1-(6,7-bis(difluoromethoxy)naphthalen-2-yl)-2-methyl-1-(1H-1,2,3-triazol-4-yl)propan-1-ol (1375603-36-3,1375603-38-5,1375603-40-9)

Guidance literature:

With tetrabutyl ammonium fluoride; cesium fluoride; In tetrahydrofuran; at 80 ℃; for 4h; Inert atmosphere;

Reference yield:

1-(6,7-Dimethoxy-naphthalen-2-yl)-2-methyl-propan-1-one (337522-30-2) → 1-(6,7-bis(difluoromethoxy)naphthalen-2-yl)-2-methyl-1-(1H-1,2,3-triazol-4-yl)propan-1-ol (1375603-36-3,1375603-38-5,1375603-40-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: boron tribromide / dichloromethane / 2 h / -40 - 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 48 h / 110 °C

3.1: tert.-butyl lithium / diethyl ether / 1 h / -78 °C / Inert atmosphere

3.2: 1 h / -78 °C

4.1: cesium fluoride; tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 80 °C / Inert atmosphere

With tetrabutyl ammonium fluoride; tert.-butyl lithium; boron tribromide; potassium carbonate; cesium fluoride; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

1-(6,7-Dihydroxy-naphthalen-2-yl)-2-methyl-propan-1-one (404964-94-9) → 1-(6,7-bis(difluoromethoxy)naphthalen-2-yl)-2-methyl-1-(1H-1,2,3-triazol-4-yl)propan-1-ol (1375603-36-3,1375603-38-5,1375603-40-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 48 h / 110 °C

2.1: tert.-butyl lithium / diethyl ether / 1 h / -78 °C / Inert atmosphere

2.2: 1 h / -78 °C

3.1: cesium fluoride; tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 80 °C / Inert atmosphere

With tetrabutyl ammonium fluoride; tert.-butyl lithium; potassium carbonate; cesium fluoride; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide;

upstream raw materials:

1-(6,7-Dimethoxy-naphthalen-2-yl)-2-methyl-propan-1-one

1-(6,7-Dihydroxy-naphthalen-2-yl)-2-methyl-propan-1-one

C₁₆H₁₄F₄O₃

C₂₄H₃₁F₄N₃O₄Si

Downstream raw materials:

(S)-seviteronel