C₂₄H₂₃F₃N₄O

Base Information

• Chemical Name: C₂₄H₂₃F₃N₄O
• CAS No.: 1416315-16-6
• Molecular Formula: C₂₄H₂₃F₃N₄O
• Molecular Weight: 440.468
• Mol file: 1416315-16-6.mol

Synonyms:

Chemical Property of C₂₄H₂₃F₃N₄O

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₄H₂₃F₃N₄O

There total 5 articles about C₂₄H₂₃F₃N₄O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

(4-(6-amino-5-bromopyridin-3-yl)phenyl)(4-methylpiperazin-1-yl)methanone (1416315-11-1) + 4-trifluoromethylphenylboronic acid (128796-39-4) → C24H23F3N4O (1416315-16-6)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; In 1,4-dioxane; water; at 90 ℃; for 14h;

DOI:10.1021/jm301476b

Reference yield:

C12H9BrN2O2 (1416315-10-0) → C24H23F3N4O (1416315-16-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: thionyl chloride / dichloromethane / Reflux

1.2: 6 h / 0 °C / Reflux

2.1: bis-triphenylphosphine-palladium(II) chloride; potassium carbonate / 1,4-dioxane; water / 14 h / 90 °C

With bis-triphenylphosphine-palladium(II) chloride; thionyl chloride; potassium carbonate; In 1,4-dioxane; dichloromethane; water;

DOI:10.1021/jm301476b

Reference yield:

1-methyl-piperazine (109-01-3) → C24H23F3N4O (1416315-16-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: thionyl chloride / dichloromethane / Reflux

1.2: 6 h / 0 °C / Reflux

2.1: bis-triphenylphosphine-palladium(II) chloride; potassium carbonate / 1,4-dioxane; water / 14 h / 90 °C

With bis-triphenylphosphine-palladium(II) chloride; thionyl chloride; potassium carbonate; In 1,4-dioxane; dichloromethane; water;

DOI:10.1021/jm301476b

upstream raw materials:

C₁₂H₉BrN₂O₂

1-methyl-piperazine

(4-(6-amino-5-bromopyridin-3-yl)phenyl)(4-methylpiperazin-1-yl)methanone

4-trifluoromethylphenylboronic acid