6-((2R,3S,4R,5R)-4-Hydroxy-2-hydroxymethyl-5-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-tetrahydro-furan-3-yloxy)-hexanoic acid 2-cyano-ethyl ester

Base Information

Chemical Name:6-((2R,3S,4R,5R)-4-Hydroxy-2-hydroxymethyl-5-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-tetrahydro-furan-3-yloxy)-hexanoic acid 2-cyano-ethyl ester
CAS No.:191853-56-2
Molecular Formula:C₂₈H₃₃N₇O₁₀
Molecular Weight:627.611
Hs Code.:

6-((2R,3S,4R,5R)-4-Hydroxy-2-hydroxymethyl-5-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-tetrahydro-furan-3-yloxy)-hexanoic acid 2-cyano-ethyl ester

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Chemical Property of 6-((2R,3S,4R,5R)-4-Hydroxy-2-hydroxymethyl-5-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-tetrahydro-furan-3-yloxy)-hexanoic acid 2-cyano-ethyl ester

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Technology Process of 6-((2R,3S,4R,5R)-4-Hydroxy-2-hydroxymethyl-5-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-tetrahydro-furan-3-yloxy)-hexanoic acid 2-cyano-ethyl ester

There total 8 articles about 6-((2R,3S,4R,5R)-4-Hydroxy-2-hydroxymethyl-5-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-tetrahydro-furan-3-yloxy)-hexanoic acid 2-cyano-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6-((2R,3R,4R,5R)-5-{6-[2-(4-Nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-4-trimethylsilanyloxy-2-trimethylsilanyloxymethyl-tetrahydro-furan-3-yloxy)-hexanoic acid 2-cyano-ethyl ester

: 191853-56-2
6-((2R,3S,4R,5R)-4-Hydroxy-2-hydroxymethyl-5-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-tetrahydro-furan-3-yloxy)-hexanoic acid 2-cyano-ethyl ester

Guidance literature:: With acetic acid; In water; for 1h; Yield given;
DOI:10.1002/hlca.19970800313

Reference yield:

: 1-methyl-3-p-nitrobenzyloxycarbonylimidazolium chloride

: 191853-56-2
6-((2R,3S,4R,5R)-4-Hydroxy-2-hydroxymethyl-5-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-tetrahydro-furan-3-yloxy)-hexanoic acid 2-cyano-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: CH₂Cl₂

2: 80percent AcOH / H₂O / 1 h

With acetic acid; In dichloromethane; water;
DOI:10.1002/hlca.19970800313

Reference yield:

: 191853-52-8
6-[(2R,3S,4R,5R)-5-(6-Amino-purin-9-yl)-4-hydroxy-2-hydroxymethyl-tetrahydro-furan-3-yloxy]-hexanoic acid 2-cyano-ethyl ester

: 191853-56-2
6-((2R,3S,4R,5R)-4-Hydroxy-2-hydroxymethyl-5-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-tetrahydro-furan-3-yloxy)-hexanoic acid 2-cyano-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: (NH₂₄)SO₄ / dioxane / 3 h / Heating

2: CH₂Cl₂

3: 80percent AcOH / H₂O / 1 h

With (NH₂₄)SO₄; acetic acid; In 1,4-dioxane; dichloromethane; water;
DOI:10.1002/hlca.19970800313