4-((E)-2-(2-hydroxy-6-((E)-4-hydroxystyryl)pyrimidin-4-yl)vinyl)phenyl dihydrogen phosphate

Base Information

• Chemical Name: 4-((E)-2-(2-hydroxy-6-((E)-4-hydroxystyryl)pyrimidin-4-yl)vinyl)phenyl dihydrogen phosphate
• CAS No.: 1387559-46-7
• Molecular Formula: C₂₀H₁₇N₂O₆P
• Molecular Weight: 412.339
• Mol file: 1387559-46-7.mol

Synonyms:

Chemical Property of 4-((E)-2-(2-hydroxy-6-((E)-4-hydroxystyryl)pyrimidin-4-yl)vinyl)phenyl dihydrogen phosphate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-((E)-2-(2-hydroxy-6-((E)-4-hydroxystyryl)pyrimidin-4-yl)vinyl)phenyl dihydrogen phosphate

There total 4 articles about 4-((E)-2-(2-hydroxy-6-((E)-4-hydroxystyryl)pyrimidin-4-yl)vinyl)phenyl dihydrogen phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C24H25N2O6P → 4-((E)-2-(2-hydroxy-6-((E)-4-hydroxystyryl)pyrimidin-4-yl)vinyl)phenyl dihydrogen phosphate (1387559-46-7)

Guidance literature:

With trimethylsilyl iodide; In dichloromethane; at 0 - 20 ℃; for 4h; Inert atmosphere;

DOI:10.1021/ja3036256

Reference yield:

4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → 4-((E)-2-(2-hydroxy-6-((E)-4-hydroxystyryl)pyrimidin-4-yl)vinyl)phenyl dihydrogen phosphate (1387559-46-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: dmap / dichloromethane / 0.17 h / 20 °C / Inert atmosphere

1.2: 10 h / 20 °C / Inert atmosphere; Cooling with ice

2.1: piperidine / pyridine / 24 h / Inert atmosphere; Reflux

3.1: trimethylsilyl iodide / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

With piperidine; dmap; trimethylsilyl iodide; In pyridine; dichloromethane;

DOI:10.1021/ja3036256

Reference yield:

4,6-dimethyl-2-hydroxy-pyrimidine hydrochloride (34289-60-6) → 4-((E)-2-(2-hydroxy-6-((E)-4-hydroxystyryl)pyrimidin-4-yl)vinyl)phenyl dihydrogen phosphate (1387559-46-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: ethanol / 1 h / 20 °C / Inert atmosphere

1.2: 24 h / Inert atmosphere; Reflux

2.1: piperidine / pyridine / 24 h / Inert atmosphere; Reflux

3.1: trimethylsilyl iodide / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

With piperidine; trimethylsilyl iodide; In pyridine; ethanol; dichloromethane;

DOI:10.1021/ja3036256

upstream raw materials:

(E)-4-(4-hydroxystyryl)-6-methylpyrimidin-2-ol

4-((diethoxyphosphoryl)oxy) benzaldehyde

4,6-dimethyl-2-hydroxy-pyrimidine hydrochloride

4-hydroxy-benzaldehyde

Refernces