N-[2-(3,4-Dichloro-phenyl)-4-oxo-butyl]-N-methyl-3-(3-trifluoromethyl-3H-diazirin-3-yl)-benzamide

Base Information

• Chemical Name: N-[2-(3,4-Dichloro-phenyl)-4-oxo-butyl]-N-methyl-3-(3-trifluoromethyl-3H-diazirin-3-yl)-benzamide
• CAS No.: 176640-07-6
• Molecular Formula: C₂₀H₁₆Cl₂F₃N₃O₂
• Molecular Weight: 458.267
• Mol file: 176640-07-6.mol

Synonyms:

Chemical Property of N-[2-(3,4-Dichloro-phenyl)-4-oxo-butyl]-N-methyl-3-(3-trifluoromethyl-3H-diazirin-3-yl)-benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[2-(3,4-Dichloro-phenyl)-4-oxo-butyl]-N-methyl-3-(3-trifluoromethyl-3H-diazirin-3-yl)-benzamide

There total 12 articles about N-[2-(3,4-Dichloro-phenyl)-4-oxo-butyl]-N-methyl-3-(3-trifluoromethyl-3H-diazirin-3-yl)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3-Bromophenyl)methanol (15852-73-0) → N-[2-(3,4-Dichloro-phenyl)-4-oxo-butyl]-N-methyl-3-(3-trifluoromethyl-3H-diazirin-3-yl)-benzamide (176640-07-6)

Guidance literature:

Multi-step reaction with 12 steps

1: 96 percent / DBU

2: 1.) BuLi / 1.) THF, -78 deg C

3: 91 percent / NH₂OH*HCl / pyridine

4: 98 percent / NEt₃, DMAP

5: 92 percent / NH₃

6: t-BuOCl

7: 85 percent / KMnO₄

8: 100 percent / SOCl₂

9: 74 percent

10: 94 percent / NaH

11: 81 percent / pTsOH

12: pyridinium chlorochromate

With dmap; potassium permanganate; n-butyllithium; thionyl chloride; tert-butylhypochlorite; hydroxylamine hydrochloride; ammonia; sodium hydride; toluene-4-sulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; pyridinium chlorochromate; In pyridine;

DOI:10.1016/0960-894X(96)00075-3

Reference yield:

1-(3-((tert-butyldimethylsilyloxy)methyl)phenyl)-2,2,2-trifluoroethanone (176640-03-2) → N-[2-(3,4-Dichloro-phenyl)-4-oxo-butyl]-N-methyl-3-(3-trifluoromethyl-3H-diazirin-3-yl)-benzamide (176640-07-6)

Guidance literature:

Multi-step reaction with 10 steps

1: 91 percent / NH₂OH*HCl / pyridine

2: 98 percent / NEt₃, DMAP

3: 92 percent / NH₃

4: t-BuOCl

5: 85 percent / KMnO₄

6: 100 percent / SOCl₂

7: 74 percent

8: 94 percent / NaH

9: 81 percent / pTsOH

10: pyridinium chlorochromate

With dmap; potassium permanganate; thionyl chloride; tert-butylhypochlorite; hydroxylamine hydrochloride; ammonia; sodium hydride; toluene-4-sulfonic acid; triethylamine; pyridinium chlorochromate; In pyridine;

DOI:10.1016/0960-894X(96)00075-3

Reference yield:

[(3-bromobenzyl)oxy](tert-butyl)dimethylsilane (103978-12-7) → N-[2-(3,4-Dichloro-phenyl)-4-oxo-butyl]-N-methyl-3-(3-trifluoromethyl-3H-diazirin-3-yl)-benzamide (176640-07-6)

Guidance literature:

Multi-step reaction with 11 steps

1: 1.) BuLi / 1.) THF, -78 deg C

2: 91 percent / NH₂OH*HCl / pyridine

3: 98 percent / NEt₃, DMAP

4: 92 percent / NH₃

5: t-BuOCl

6: 85 percent / KMnO₄

7: 100 percent / SOCl₂

8: 74 percent

9: 94 percent / NaH

10: 81 percent / pTsOH

11: pyridinium chlorochromate

With dmap; potassium permanganate; n-butyllithium; thionyl chloride; tert-butylhypochlorite; hydroxylamine hydrochloride; ammonia; sodium hydride; toluene-4-sulfonic acid; triethylamine; pyridinium chlorochromate; In pyridine;

DOI:10.1016/0960-894X(96)00075-3

upstream raw materials:

N-[2-(3,4-Dichloro-phenyl)-4-hydroxy-butyl]-N-methyl-3-(3-trifluoromethyl-3H-diazirin-3-yl)-benzamide

(3-Bromophenyl)methanol

[(3-bromobenzyl)oxy](tert-butyl)dimethylsilane

3-[3-hydroxymethylphenyl]-3-trifluoromethyl-3H-diazirine