Technology Process of 3-((S)-5-Hydroxy-2,6,6-trimethyl-cyclohex-1-enyl)-propionic acid methyl ester
There total 19 articles about 3-((S)-5-Hydroxy-2,6,6-trimethyl-cyclohex-1-enyl)-propionic acid methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 15 steps
1: LiAlH4 / diethyl ether / 1.) 1 h, reflux, 2.) 1.5 h, r.t.
2: acetic acid / H2O / 1 h / 60 °C
3: pyridine / 72 h / Ambient temperature
4: 1.) H2, 2.) CrO3, conc. H2SO4 / 1.) 5percent Rh/C / 1.) EtOH, 46 h, 2.) H2O, acetone
6: diethyl ether / 0.5 h / Ambient temperature
8: pyridine
9: 70 percent / Na2HPO4, trifluoroperacetic acid / CH2Cl2
10: 5percent aq. KOH / ethanol / 20 h / 60 °C
11: diethyl ether
12: pyridine / 50 °C
13: thionyl chloride, pyridine
14: 1.0 N CH3ONa / methanol / 48 h / Ambient temperature
15: diethyl ether
With
pyridine; chromium(VI) oxide; potassium hydroxide; disodium hydrogenphosphate; lithium aluminium tetrahydride; thionyl chloride; trifluoroacetyl peroxide; sulfuric acid; hydrogen; sodium methylate; acetic acid;
Rh on carbon;
In
methanol; diethyl ether; ethanol; dichloromethane; water;
DOI:10.1002/hlca.19810640402
- Guidance literature:
-
Multi-step reaction with 13 steps
1: pyridine / 72 h / Ambient temperature
2: 1.) H2, 2.) CrO3, conc. H2SO4 / 1.) 5percent Rh/C / 1.) EtOH, 46 h, 2.) H2O, acetone
4: diethyl ether / 0.5 h / Ambient temperature
6: pyridine
7: 70 percent / Na2HPO4, trifluoroperacetic acid / CH2Cl2
8: 5percent aq. KOH / ethanol / 20 h / 60 °C
9: diethyl ether
10: pyridine / 50 °C
11: thionyl chloride, pyridine
12: 1.0 N CH3ONa / methanol / 48 h / Ambient temperature
13: diethyl ether
With
pyridine; chromium(VI) oxide; potassium hydroxide; disodium hydrogenphosphate; thionyl chloride; trifluoroacetyl peroxide; sulfuric acid; hydrogen; sodium methylate;
Rh on carbon;
In
methanol; diethyl ether; ethanol; dichloromethane;
DOI:10.1002/hlca.19810640402
- Guidance literature:
-
Multi-step reaction with 14 steps
1: acetic acid / H2O / 1 h / 60 °C
2: pyridine / 72 h / Ambient temperature
3: 1.) H2, 2.) CrO3, conc. H2SO4 / 1.) 5percent Rh/C / 1.) EtOH, 46 h, 2.) H2O, acetone
5: diethyl ether / 0.5 h / Ambient temperature
7: pyridine
8: 70 percent / Na2HPO4, trifluoroperacetic acid / CH2Cl2
9: 5percent aq. KOH / ethanol / 20 h / 60 °C
10: diethyl ether
11: pyridine / 50 °C
12: thionyl chloride, pyridine
13: 1.0 N CH3ONa / methanol / 48 h / Ambient temperature
14: diethyl ether
With
pyridine; chromium(VI) oxide; potassium hydroxide; disodium hydrogenphosphate; thionyl chloride; trifluoroacetyl peroxide; sulfuric acid; hydrogen; sodium methylate; acetic acid;
Rh on carbon;
In
methanol; diethyl ether; ethanol; dichloromethane; water;
DOI:10.1002/hlca.19810640402
