Technology Process of 3-chlorobenzofuran-5-carboxylic acid
There total 6 articles about 3-chlorobenzofuran-5-carboxylic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
methyl 3-chlorobenzofuran-5-carboxylate;
With
water; sodium hydroxide;
In
methanol;
at 20 ℃;
for 12h;
pH=3;
Acidic conditions;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 15 h / 20 °C / Inert atmosphere
2.1: sodium carbonate; sodium formate; tetrabutyl-ammonium chloride; palladium diacetate / N,N-dimethyl-formamide / 48 h / 80 °C / Inert atmosphere
3.1: sodium hydroxide / water; methanol / 15 h / 20 °C
3.2: pH 5
4.1: sulfuryl dichloride / dichloromethane / 4 h / 25 °C
5.1: potassium carbonate / ethanol / 1 h / 25 °C
6.1: water; sodium hydroxide / methanol / 12 h / 20 °C
6.2: pH 3 / Acidic conditions
With
sulfuryl dichloride; tetrabutyl-ammonium chloride; water; sodium formate; palladium diacetate; sodium hydride; sodium carbonate; potassium carbonate; sodium hydroxide;
In
methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium carbonate; sodium formate; tetrabutyl-ammonium chloride; palladium diacetate / N,N-dimethyl-formamide / 48 h / 80 °C / Inert atmosphere
2.1: sodium hydroxide / water; methanol / 15 h / 20 °C
2.2: pH 5
3.1: sulfuryl dichloride / dichloromethane / 4 h / 25 °C
4.1: potassium carbonate / ethanol / 1 h / 25 °C
5.1: water; sodium hydroxide / methanol / 12 h / 20 °C
5.2: pH 3 / Acidic conditions
With
sulfuryl dichloride; tetrabutyl-ammonium chloride; water; sodium formate; palladium diacetate; sodium carbonate; potassium carbonate; sodium hydroxide;
In
methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;