ethyl 2-oxo-4-(2-oxo-2-phenylethyl)-5-phenyltetrahydro-3-furancarboxylate

Base Information

Chemical Name:ethyl 2-oxo-4-(2-oxo-2-phenylethyl)-5-phenyltetrahydro-3-furancarboxylate
CAS No.:453537-89-8
Molecular Formula:C₂₁H₂₀O₅
Molecular Weight:352.387
Hs Code.:

Synonyms:

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Chemical Property of ethyl 2-oxo-4-(2-oxo-2-phenylethyl)-5-phenyltetrahydro-3-furancarboxylate

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Technology Process of ethyl 2-oxo-4-(2-oxo-2-phenylethyl)-5-phenyltetrahydro-3-furancarboxylate

There total 2 articles about ethyl 2-oxo-4-(2-oxo-2-phenylethyl)-5-phenyltetrahydro-3-furancarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 23637-56-1
3,6-diphenyl-3,6-dihydro-1,2-dioxine

: 453537-89-8
ethyl 2-oxo-4-(2-oxo-2-phenylethyl)-5-phenyltetrahydro-3-furancarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: [(R,R)-(MeCOC((-)-menthoxy-CO)CHNCHPh)2]Co / tetrahydrofuran / 3 h / -4 °C

2: sodium ethoxide / tetrahydrofuran / 16 h / 20 °C

With sodium ethanolate; [(R,R)-(MeCOC((-)-menthoxy-CO)CHNCHPh)2]Co; In tetrahydrofuran;
DOI:10.1021/jo0200421

Reference yield:

: 996-82-7,34727-00-9,73177-21-6
sodium diethylmalonate

: 23637-56-1
3,6-diphenyl-3,6-dihydro-1,2-dioxine

: 453537-89-8
ethyl 2-oxo-4-(2-oxo-2-phenylethyl)-5-phenyltetrahydro-3-furancarboxylate

: ethyl 2-oxo-4-(2-oxo-2-phenylethyl)-5-phenyltetrahydro-3-furancarboxylate

Guidance literature:: 3,6-diphenyl-3,6-dihydro-1,2-dioxine; With C₂₂H₂₆N₂O₃; In tetrahydrofuran; at 20 ℃; for 16h; Inert atmosphere;

sodium diethylmalonate; In tetrahydrofuran; at 0 - 20 ℃; for 16h; Inert atmosphere;

With hydrogenchloride; water; In tetrahydrofuran; at 0 ℃; Overall yield = 44 %;
DOI:10.1021/jo400177j

Reference yield:

: 589-15-1
1-bromomethyl-4-bromobenzene

: 453537-89-8
ethyl 2-oxo-4-(2-oxo-2-phenylethyl)-5-phenyltetrahydro-3-furancarboxylate

: (4S,5R)-3-(4-Bromo-benzyl)-2-oxo-4-(2-oxo-2-phenyl-ethyl)-5-phenyl-tetrahydro-furan-3-carboxylic acid ethyl ester

Guidance literature:: ethyl 2-oxo-4-(2-oxo-2-phenylethyl)-5-phenyltetrahydro-3-furancarboxylate; With sodium ethanolate; In tetrahydrofuran; for 0.5h;

1-bromomethyl-4-bromobenzene; In tetrahydrofuran; at 20 ℃; for 16h; Further stages.;
DOI:10.1021/jo0200421