7-Chloro-8-fluoropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione

Base Information

Chemical Name:7-Chloro-8-fluoropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione
CAS No.:2454397-75-0
Molecular Formula:C₇H₃ClFN₃O₂
Molecular Weight:215.571
Hs Code.:

Synonyms:

Suppliers and Price of 7-Chloro-8-fluoropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 10 raw suppliers

Chemical Property of 7-Chloro-8-fluoropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione

Chemical Property:

Purity/Quality:: 99%, ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 7-Chloro-8-fluoropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione

There total 6 articles about 7-Chloro-8-fluoropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2454397-74-9
ethyl 4-amino-6-chloro-5-fluoropyridine-3-carboxylate

: 3019-71-4
Trichloroacetyl isocyanate

: 2454397-75-0
7-Chloro-8-fluoropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione

Guidance literature:: ethyl 4-amino-6-chloro-5-fluoropyridine-3-carboxylate; Trichloroacetyl isocyanate; In tetrahydrofuran; at 0 - 20 ℃; for 0.5h;

With ammonia; In methanol; at 0 - 20 ℃; for 16h;

Reference yield:

: 154012-18-7
2,4-dichloro-3-fluoropyridine-5-carboxylic acid

: 2454397-75-0
7-Chloro-8-fluoropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: thionyl chloride / 65 - 80 °C

2.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 18 h / 40 °C

3.1: trifluoroacetic acid / dichloromethane / 0.75 h / 0 °C

4.1: tetrahydrofuran / 0.5 h / 0 - 20 °C

4.2: 16 h / 0 - 20 °C

With thionyl chloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane;

Reference yield:

: 628691-93-0
2-chloro-3-fluoro-pyridine-4-carboxylic acid

: 2454397-75-0
7-Chloro-8-fluoropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / toluene / 0.5 h / 110 °C / Molecular sieve; Inert atmosphere; Large scale

1.2: 5 h / 110 °C / Inert atmosphere; Large scale

2.1: hydrogenchloride / 1,4-dioxane; acetonitrile / 2 h / 25 °C

3.1: N-iodo-succinimide; toluene-4-sulfonic acid / acetonitrile; water / 16 h / 70 °C

4.1: bis-triphenylphosphine-palladium(II) chloride; triethylamine / 15 h / 80 °C / 775.74 Torr

5.1: tetrahydrofuran / 0.5 h / 0 - 20 °C

5.2: 16 h / 0 - 20 °C

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; N-iodo-succinimide; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; 1,4-dioxane; water; toluene; acetonitrile;