2-Methoxy-alpha-methyl-N-(phenylmethyl)benzenemethanamine

Base Information

• Chemical Name: 2-Methoxy-alpha-methyl-N-(phenylmethyl)benzenemethanamine
• CAS No.: 138852-33-2
• Molecular Formula: C16H19NO
• Molecular Weight: 241.333
• DSSTox Substance ID: DTXSID401215189
• Mol file: 138852-33-2.mol

Synonyms:2-Methoxy-alpha-methyl-N-(phenylmethyl)benzenemethanamine;DTXSID401215189;AKOS000226121;AKOS017265934;138852-33-2

Chemical Property of 2-Methoxy-alpha-methyl-N-(phenylmethyl)benzenemethanamine

Chemical Property:

• XLogP3: 3.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 241.146664230
• Heavy Atom Count: 18
• Complexity: 225

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(C1=CC=CC=C1OC)NCC2=CC=CC=C2

Technology Process of 2-Methoxy-alpha-methyl-N-(phenylmethyl)benzenemethanamine

There total 2 articles about 2-Methoxy-alpha-methyl-N-(phenylmethyl)benzenemethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-Methoxyacetophenone (579-74-8) + benzylamine (100-46-9) → N-benzyl-1- (2-methoxyphenyl)ethan-1-amine (138852-33-2)

Guidance literature:

With bis(1,5-cyclooctadiene)diiridium(I) dichloride; hydrogen; In toluene; at 90 ℃; for 24h; under 37503.8 Torr; Autoclave;

DOI:10.1002/chem.201803094

Reference yield: 83.0%

N-benzyl-1-imino-1-(2-methoxyphenyl)ethane (120343-41-1) → N-benzyl-1- (2-methoxyphenyl)ethan-1-amine (138852-33-2)

Guidance literature:

With iron(III)-acetylacetonate; [2,5-(SiMe3)2-3,4-(CH2)4(η5-C4CO)Fe(CO)2(PhCN); isopropyl alcohol; at 110 ℃; for 48h; Inert atmosphere; Sealed tube;

DOI:10.1039/c5ob02119g

Reference yield:

N-benzyl-1- (2-methoxyphenyl)ethan-1-amine (138852-33-2) → 1-(2-methoxyphenyl)ethanamine (40023-74-3,62409-14-7,68285-23-4,68285-24-5)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; In Isopropyl acetate; at 55 ℃; for 24h;

DOI:10.1002/adsc.201100250

upstream raw materials:

2-Methoxyacetophenone

benzylamine

N-benzyl-1-imino-1-(2-methoxyphenyl)ethane

Downstream raw materials:

2,2,2-trifluoro-N-(1-(2-methoxyphenyl)ethyl)acetamide

1-(2-methoxyphenyl)ethanamine