(2R,4aR,6R,7R,8R,8aS)-8-((2S,3S,4R,5R,6R)-4,5-Bis-benzyloxy-6-benzyloxymethyl-3-hydroxy-tetrahydro-pyran-2-ylmethyl)-6-methoxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-ol

Base Information

Chemical Name:(2R,4aR,6R,7R,8R,8aS)-8-((2S,3S,4R,5R,6R)-4,5-Bis-benzyloxy-6-benzyloxymethyl-3-hydroxy-tetrahydro-pyran-2-ylmethyl)-6-methoxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-ol
CAS No.:384819-77-6
Molecular Formula:C₄₂H₄₈O₁₀
Molecular Weight:712.837
Hs Code.:

(2R,4aR,6R,7R,8R,8aS)-8-((2S,3S,4R,5R,6R)-4,5-Bis-benzyloxy-6-benzyloxymethyl-3-hydroxy-tetrahydro-pyran-2-ylmethyl)-6-methoxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-ol

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Chemical Property of (2R,4aR,6R,7R,8R,8aS)-8-((2S,3S,4R,5R,6R)-4,5-Bis-benzyloxy-6-benzyloxymethyl-3-hydroxy-tetrahydro-pyran-2-ylmethyl)-6-methoxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-ol

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Technology Process of (2R,4aR,6R,7R,8R,8aS)-8-((2S,3S,4R,5R,6R)-4,5-Bis-benzyloxy-6-benzyloxymethyl-3-hydroxy-tetrahydro-pyran-2-ylmethyl)-6-methoxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-ol

There total 9 articles about (2R,4aR,6R,7R,8R,8aS)-8-((2S,3S,4R,5R,6R)-4,5-Bis-benzyloxy-6-benzyloxymethyl-3-hydroxy-tetrahydro-pyran-2-ylmethyl)-6-methoxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₄₄H₅₂O₁₀Si

: 384819-77-6
(2R,4aR,6R,7R,8R,8aS)-8-((2S,3S,4R,5R,6R)-4,5-Bis-benzyloxy-6-benzyloxymethyl-3-hydroxy-tetrahydro-pyran-2-ylmethyl)-6-methoxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-ol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran;
DOI:10.1016/S0040-4039(01)01533-7

Reference yield:

: 51532-75-3,16697-49-7,68681-00-5,68779-52-2,78418-56-1,125135-29-7,130694-47-2,130694-49-4,146864-77-9
3,4,6-tri-O-benzyl-1,2-O-(1-methoxyethylidene)-α-D-glucopyranose

: 384819-77-6
(2R,4aR,6R,7R,8R,8aS)-8-((2S,3S,4R,5R,6R)-4,5-Bis-benzyloxy-6-benzyloxymethyl-3-hydroxy-tetrahydro-pyran-2-ylmethyl)-6-methoxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-ol

Guidance literature:: Multi-step reaction with 6 steps

1.1: AcOH / H₂O / 20 °C

1.2: PCC; 4 Angstroem mol. sieves / CH₂Cl₂ / 20 °C

2.1: tetrahydrofuran; pyridine / -40 - 20 °C

3.1: MeONa / methanol / 20 °C

4.1: DMAP / tetrahydrofuran

5.1: Bu₃SnH; AIBN / toluene / 17 h / Heating

6.1: TBAF / tetrahydrofuran

With dmap; 2,2'-azobis(isobutyronitrile); tetrabutyl ammonium fluoride; tri-n-butyl-tin hydride; sodium methylate; acetic acid; In tetrahydrofuran; pyridine; methanol; water; toluene; 2.1: Tebbe methylenation;
DOI:10.1016/S0040-4039(01)01533-7

Reference yield:

: 117605-32-0
methyl 4,6-O-benzylidene-3-deoxy-3-iodo-β-D-allopyranoside

: 384819-77-6
(2R,4aR,6R,7R,8R,8aS)-8-((2S,3S,4R,5R,6R)-4,5-Bis-benzyloxy-6-benzyloxymethyl-3-hydroxy-tetrahydro-pyran-2-ylmethyl)-6-methoxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: BuLi / tetrahydrofuran

1.2: tetrahydrofuran

2.1: DMAP / tetrahydrofuran

3.1: Bu₃SnH; AIBN / toluene / 17 h / Heating

4.1: TBAF / tetrahydrofuran

With dmap; n-butyllithium; 2,2'-azobis(isobutyronitrile); tetrabutyl ammonium fluoride; tri-n-butyl-tin hydride; In tetrahydrofuran; toluene;
DOI:10.1016/S0040-4039(01)01533-7