2',3'-O-<<methyl>ethoxymethylidene>-2,3-O-(methoxyethylidene)-1,2-di(adenosin-N⁶-yl)ethane

Base Information

• Chemical Name: 2',3'-O-<<methyl>ethoxymethylidene>-2,3-O-(methoxyethylidene)-1,2-di(adenosin-N⁶-yl)ethane
• CAS No.: 73644-57-2
• Molecular Formula: C₃₇H₄₅N₁₁O₁₂
• Molecular Weight: 835.831

Synonyms:

Chemical Property of 2',3'-O-<<methyl>ethoxymethylidene>-2,3-O-(methoxyethylidene)-1,2-di(adenosin-N⁶-yl)ethane

Chemical Property:

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Technology Process of 2',3'-O-<<methyl>ethoxymethylidene>-2,3-O-(methoxyethylidene)-1,2-di(adenosin-N⁶-yl)ethane

There total 4 articles about 2',3'-O-<<methyl>ethoxymethylidene>-2,3-O-(methoxyethylidene)-1,2-di(adenosin-N⁶-yl)ethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

6-chloro-9-<2,3-O-(methoxyethylidene)-β-D-ribofuranosyl>purine (73644-53-8) + 2',3'-O-<<methyl>ethoxymethylidene>-N6-(2-aminoethyl)adenosine → 2',3'-O-<<methyl>ethoxymethylidene>-2,3-O-(methoxyethylidene)-1,2-di(adenosin-N6-yl)ethane (73644-57-2)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; for 18h; Ambient temperature;

DOI:10.1021/jm00181a015

Reference yield:

N6-(2-Aminoethyl)adenosine (35662-04-5) → 2',3'-O-<<methyl>ethoxymethylidene>-2,3-O-(methoxyethylidene)-1,2-di(adenosin-N6-yl)ethane (73644-57-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 60 mg / CF₃COOH / dimethylformamide / 6.5 h / Ambient temperature

2: 20 percent / Et₃N / dimethylformamide / 18 h / Ambient temperature

With triethylamine; trifluoroacetic acid; In N,N-dimethyl-formamide;

DOI:10.1021/jm00181a015

Reference yield:

ethyl N-benzyloxycarbonylamino-orthoacetate (13347-35-8) → 2',3'-O-<<methyl>ethoxymethylidene>-2,3-O-(methoxyethylidene)-1,2-di(adenosin-N6-yl)ethane (73644-57-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 60 mg / CF₃COOH / dimethylformamide / 6.5 h / Ambient temperature

2: 20 percent / Et₃N / dimethylformamide / 18 h / Ambient temperature

With triethylamine; trifluoroacetic acid; In N,N-dimethyl-formamide;

DOI:10.1021/jm00181a015

upstream raw materials:

6-chloro-9-<2,3-O-(methoxyethylidene)-β-D-ribofuranosyl>purine

N₆-(2-Aminoethyl)adenosine

ethyl N-benzyloxycarbonylamino-orthoacetate

6-Chloropurine riboside

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