allyl (3S,4R,5S)-4-{(S)-2-[(R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propionylamino]-3-(tritylthio)propionylamino}-3-hydroxy-5-methylheptanoate

Base Information

Chemical Name:allyl (3S,4R,5S)-4-{(S)-2-[(R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propionylamino]-3-(tritylthio)propionylamino}-3-hydroxy-5-methylheptanoate
CAS No.:1309766-88-8
Molecular Formula:C₅₁H₅₅N₃O₇S
Molecular Weight:854.08
Hs Code.:

allyl (3S,4R,5S)-4-{(S)-2-[(R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propionylamino]-3-(tritylthio)propionylamino}-3-hydroxy-5-methylheptanoate

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of allyl (3S,4R,5S)-4-{(S)-2-[(R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propionylamino]-3-(tritylthio)propionylamino}-3-hydroxy-5-methylheptanoate

Chemical Property:

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Technology Process of allyl (3S,4R,5S)-4-{(S)-2-[(R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propionylamino]-3-(tritylthio)propionylamino}-3-hydroxy-5-methylheptanoate

There total 6 articles about allyl (3S,4R,5S)-4-{(S)-2-[(R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propionylamino]-3-(tritylthio)propionylamino}-3-hydroxy-5-methylheptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₃H₄₀N₂O₄S

: 35661-38-2,35661-39-3,79990-15-1,136132-75-7
N-(9-fluorenylmethoxycarbonyl)-D-alanine

: 1309766-88-8
allyl (3S,4R,5S)-4-{(S)-2-[(R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propionylamino]-3-(tritylthio)propionylamino}-3-hydroxy-5-methylheptanoate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 2h;
DOI:10.1039/c0ob01169j

Reference yield:

: ethyl (4R,5S)-4-(t-butoxycarbonylamino)-3-hydroxy-5-methylheptanoate

: 1309766-88-8
allyl (3S,4R,5S)-4-{(S)-2-[(R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propionylamino]-3-(tritylthio)propionylamino}-3-hydroxy-5-methylheptanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: water; lithium hydroxide / tetrahydrofuran / 1 h / 0 - 20 °C

1.2: 0 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 1.5 h / 20 °C

3.1: hydrogenchloride / 1,4-dioxane / 2 h / 0 - 20 °C

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 0 - 20 °C

5.1: diethylamine / dichloromethane / 2 h / 20 °C

6.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C

With hydrogenchloride; water; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diethylamine; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c0ob01169j

Reference yield:

: C₁₁H₂₁NO₃*ClH

: 1309766-88-8
allyl (3S,4R,5S)-4-{(S)-2-[(R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propionylamino]-3-(tritylthio)propionylamino}-3-hydroxy-5-methylheptanoate

Guidance literature:: Multi-step reaction with 3 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 0 - 20 °C

2: diethylamine / dichloromethane / 2 h / 20 °C

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c0ob01169j