N-(3-cyano-4-(4-fluorophenyl)-7,7-dimethyl-5-oxo-1-(4-sulfamoylphenyl)-1,4,5,6,7,8-hexahydroquinolin-2-yl)-3-oxobutanamide

Base Information

• Chemical Name: N-(3-cyano-4-(4-fluorophenyl)-7,7-dimethyl-5-oxo-1-(4-sulfamoylphenyl)-1,4,5,6,7,8-hexahydroquinolin-2-yl)-3-oxobutanamide
• CAS No.: 1215008-10-8
• Molecular Formula: C₂₈H₂₇FN₄O₅S
• Molecular Weight: 550.611
• Mol file: 1215008-10-8.mol

Synonyms:

Chemical Property of N-(3-cyano-4-(4-fluorophenyl)-7,7-dimethyl-5-oxo-1-(4-sulfamoylphenyl)-1,4,5,6,7,8-hexahydroquinolin-2-yl)-3-oxobutanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(3-cyano-4-(4-fluorophenyl)-7,7-dimethyl-5-oxo-1-(4-sulfamoylphenyl)-1,4,5,6,7,8-hexahydroquinolin-2-yl)-3-oxobutanamide

There total 3 articles about N-(3-cyano-4-(4-fluorophenyl)-7,7-dimethyl-5-oxo-1-(4-sulfamoylphenyl)-1,4,5,6,7,8-hexahydroquinolin-2-yl)-3-oxobutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

4-[2-amino-3-cyano-4-(4-fluoro-phenyl)-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-4H-quinolin-1-yl]benzenesulfonamide (1019911-89-7) + ethyl acetoacetate (141-97-9) → N-(3-cyano-4-(4-fluorophenyl)-7,7-dimethyl-5-oxo-1-(4-sulfamoylphenyl)-1,4,5,6,7,8-hexahydroquinolin-2-yl)-3-oxobutanamide (1215008-10-8)

Guidance literature:

for 5h; Reflux;

DOI:10.1007/s00044-010-9332-3

Reference yield:

4-(5,5-dimethyl-3-oxo-cyclohex-1-enylamino)benzenesulfonamide (93536-06-2) → N-(3-cyano-4-(4-fluorophenyl)-7,7-dimethyl-5-oxo-1-(4-sulfamoylphenyl)-1,4,5,6,7,8-hexahydroquinolin-2-yl)-3-oxobutanamide (1215008-10-8)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / ethanol / 6 h / Reflux

2: 5 h / Reflux

With triethylamine; In ethanol;

DOI:10.1007/s00044-010-9332-3

Reference yield:

sulfanilamide (63-74-1) → N-(3-cyano-4-(4-fluorophenyl)-7,7-dimethyl-5-oxo-1-(4-sulfamoylphenyl)-1,4,5,6,7,8-hexahydroquinolin-2-yl)-3-oxobutanamide (1215008-10-8)

Guidance literature:

Multi-step reaction with 3 steps

1: ethanol

2: triethylamine / ethanol / 6 h / Reflux

3: 5 h / Reflux

With triethylamine; In ethanol;

DOI:10.1007/s00044-010-9332-3

upstream raw materials:

4-[2-amino-3-cyano-4-(4-fluoro-phenyl)-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-4H-quinolin-1-yl]benzenesulfonamide

ethyl acetoacetate

4-(5,5-dimethyl-3-oxo-cyclohex-1-enylamino)benzenesulfonamide

sulfanilamide