4-Benzyl-2-hydroxy-3-[1-(6-methoxymethoxy-7-methyl-benzo[1,3]dioxol-5-yl)-meth-(Z)-ylidene]-5-oxo-6-(2,4,5-trimethoxy-3-methyl-benzyl)-piperazine-1-carboxylic acid isopropyl ester

Base Information

• Chemical Name: 4-Benzyl-2-hydroxy-3-[1-(6-methoxymethoxy-7-methyl-benzo[1,3]dioxol-5-yl)-meth-(Z)-ylidene]-5-oxo-6-(2,4,5-trimethoxy-3-methyl-benzyl)-piperazine-1-carboxylic acid isopropyl ester
• CAS No.: 187040-10-4
• Molecular Formula: C₃₇H₄₄N₂O₁₁
• Molecular Weight: 692.763

Synonyms:

Chemical Property of 4-Benzyl-2-hydroxy-3-[1-(6-methoxymethoxy-7-methyl-benzo[1,3]dioxol-5-yl)-meth-(Z)-ylidene]-5-oxo-6-(2,4,5-trimethoxy-3-methyl-benzyl)-piperazine-1-carboxylic acid isopropyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Benzyl-2-hydroxy-3-[1-(6-methoxymethoxy-7-methyl-benzo[1,3]dioxol-5-yl)-meth-(Z)-ylidene]-5-oxo-6-(2,4,5-trimethoxy-3-methyl-benzyl)-piperazine-1-carboxylic acid isopropyl ester

There total 11 articles about 4-Benzyl-2-hydroxy-3-[1-(6-methoxymethoxy-7-methyl-benzo[1,3]dioxol-5-yl)-meth-(Z)-ylidene]-5-oxo-6-(2,4,5-trimethoxy-3-methyl-benzyl)-piperazine-1-carboxylic acid isopropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,4-methylenedioxyphenyl formate (80592-18-3) → 4-Benzyl-2-hydroxy-3-[1-(6-methoxymethoxy-7-methyl-benzo[1,3]dioxol-5-yl)-meth-(Z)-ylidene]-5-oxo-6-(2,4,5-trimethoxy-3-methyl-benzyl)-piperazine-1-carboxylic acid isopropyl ester (187040-10-4)

Guidance literature:

Multi-step reaction with 11 steps

1: 10percent aq. KOH / methanol / 2.5 h / Ambient temperature

2: 99 percent / NaH / dimethylformamide / 1.) 0 deg C, 30 min, 2.) 0 deg C, 3 h

3: 72 percent / BuLi / tetrahydrofuran / 1.) -17 deg C, 1 h, 2.) -17 deg C, 2 h

4: 77 percent / conc. aq. HCl / ethanol / 3 h / Heating

5: 73 percent / acetic acid / 0.5 h / Heating

6: 94 percent / NaH / dimethylformamide / 1.) 0 deg C, 30 min, 2.) 0 deg C, 1 h

7: 84 percent / t-BuOK / 2-methyl-propan-2-ol; dimethylformamide / 24 h / Ambient temperature

8: NaH / dimethylformamide / 1.) 0 deg C, 30 min, 2.) r.t., 2 h

9: NH₂NH₂*H₂O / dimethylformamide / 1 h / Ambient temperature

10: 98 percent / Et₃N, DMAP / CH₂Cl₂ / 3 h / Ambient temperature

11: LiAl(O-t-Bu)3H / tetrahydrofuran / 1 h / 0 °C

With hydrogenchloride; dmap; potassium hydroxide; n-butyllithium; potassium tert-butylate; sodium hydride; hydrazine hydrate; lithium tri-t-butoxyaluminum hydride; triethylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane; acetic acid; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

Sesamol (533-31-3) → 4-Benzyl-2-hydroxy-3-[1-(6-methoxymethoxy-7-methyl-benzo[1,3]dioxol-5-yl)-meth-(Z)-ylidene]-5-oxo-6-(2,4,5-trimethoxy-3-methyl-benzyl)-piperazine-1-carboxylic acid isopropyl ester (187040-10-4)

Guidance literature:

Multi-step reaction with 10 steps

1: 99 percent / NaH / dimethylformamide / 1.) 0 deg C, 30 min, 2.) 0 deg C, 3 h

2: 72 percent / BuLi / tetrahydrofuran / 1.) -17 deg C, 1 h, 2.) -17 deg C, 2 h

3: 77 percent / conc. aq. HCl / ethanol / 3 h / Heating

4: 73 percent / acetic acid / 0.5 h / Heating

5: 94 percent / NaH / dimethylformamide / 1.) 0 deg C, 30 min, 2.) 0 deg C, 1 h

6: 84 percent / t-BuOK / 2-methyl-propan-2-ol; dimethylformamide / 24 h / Ambient temperature

7: NaH / dimethylformamide / 1.) 0 deg C, 30 min, 2.) r.t., 2 h

8: NH₂NH₂*H₂O / dimethylformamide / 1 h / Ambient temperature

9: 98 percent / Et₃N, DMAP / CH₂Cl₂ / 3 h / Ambient temperature

10: LiAl(O-t-Bu)3H / tetrahydrofuran / 1 h / 0 °C

With hydrogenchloride; dmap; n-butyllithium; potassium tert-butylate; sodium hydride; hydrazine hydrate; lithium tri-t-butoxyaluminum hydride; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; acetic acid; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

piperonal (120-57-0,30024-74-9) → 4-Benzyl-2-hydroxy-3-[1-(6-methoxymethoxy-7-methyl-benzo[1,3]dioxol-5-yl)-meth-(Z)-ylidene]-5-oxo-6-(2,4,5-trimethoxy-3-methyl-benzyl)-piperazine-1-carboxylic acid isopropyl ester (187040-10-4)

Guidance literature:

Multi-step reaction with 12 steps

1: m-CPBA / CH₂Cl₂ / 4 h / Heating

2: 10percent aq. KOH / methanol / 2.5 h / Ambient temperature

3: 99 percent / NaH / dimethylformamide / 1.) 0 deg C, 30 min, 2.) 0 deg C, 3 h

4: 72 percent / BuLi / tetrahydrofuran / 1.) -17 deg C, 1 h, 2.) -17 deg C, 2 h

5: 77 percent / conc. aq. HCl / ethanol / 3 h / Heating

6: 73 percent / acetic acid / 0.5 h / Heating

7: 94 percent / NaH / dimethylformamide / 1.) 0 deg C, 30 min, 2.) 0 deg C, 1 h

8: 84 percent / t-BuOK / 2-methyl-propan-2-ol; dimethylformamide / 24 h / Ambient temperature

9: NaH / dimethylformamide / 1.) 0 deg C, 30 min, 2.) r.t., 2 h

10: NH₂NH₂*H₂O / dimethylformamide / 1 h / Ambient temperature

11: 98 percent / Et₃N, DMAP / CH₂Cl₂ / 3 h / Ambient temperature

12: LiAl(O-t-Bu)3H / tetrahydrofuran / 1 h / 0 °C

With hydrogenchloride; dmap; potassium hydroxide; n-butyllithium; potassium tert-butylate; sodium hydride; hydrazine hydrate; lithium tri-t-butoxyaluminum hydride; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; ethanol; dichloromethane; acetic acid; N,N-dimethyl-formamide; tert-butyl alcohol;

upstream raw materials:

3,4-methylenedioxyphenyl formate

Sesamol

piperonal

3,4-(methylenedioxy)phenyl methoxymethyl ether

Downstream raw materials:

1-Benzyl-6-(6-hydroxy-7-methyl-benzo[1,3]dioxol-5-ylmethyl)-3-(2,4,5-trimethoxy-3-methyl-benzyl)-1H-pyrazin-2-one

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 187040-10-4 4-Benzyl-2-hydroxy-3-[1-(6-methoxymethoxy-7-methyl-benzo[1,3]dioxol-5-yl)-meth-(Z)-ylidene]-5-oxo-6-(2,4,5-trimethoxy-3-methyl-benzyl)-piperazine-1-carboxylic acid isopropyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send