6-(4-[4-[¹⁸F]fluoro-3-hydroxybenzyl]piperazine-1-yl)benzodioxin

Base Information

• Chemical Name: 6-(4-[4-[¹⁸F]fluoro-3-hydroxybenzyl]piperazine-1-yl)benzodioxin
• CAS No.: 1350900-77-4
• Molecular Formula: C₁₉H₂₁FN₂O₃
• Molecular Weight: 343.387
• Mol file: 1350900-77-4.mol

Synonyms:

Chemical Property of 6-(4-[4-[¹⁸F]fluoro-3-hydroxybenzyl]piperazine-1-yl)benzodioxin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-(4-[4-[¹⁸F]fluoro-3-hydroxybenzyl]piperazine-1-yl)benzodioxin

There total 8 articles about 6-(4-[4-[¹⁸F]fluoro-3-hydroxybenzyl]piperazine-1-yl)benzodioxin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C26H27(18)FN2O3 (1535195-99-3) → 6-(4-[4-[18F]fluoro-3-hydroxybenzyl]piperazine-1-yl)benzodioxin (1350900-77-4)

Guidance literature:

With ammonium formate; palladium; In methanol; at 60 ℃; for 0.133333h; Inert atmosphere;

DOI:10.1002/jlcr.3074

Reference yield:

2-benzyloxy-4-formyl-N,N,N-trimethylanilinium trifluoromethanesulfonate → 6-(4-[4-[18F]fluoro-3-hydroxybenzyl]piperazine-1-yl)benzodioxin (1350900-77-4)

Guidance literature:

Multi-step reaction with 3 steps

1: (¹⁸F)-fluoride / dimethyl sulfoxide

2: ammonium formate; palladium

3: sodium cyanoborohydride; acetic acid / dimethyl sulfoxide / 2 h / 110 °C

With (¹⁸F)-fluoride; ammonium formate; sodium cyanoborohydride; palladium; acetic acid; In dimethyl sulfoxide;

DOI:10.1021/jm200762g

Reference yield:

6-amino-3,4-benzodioxane (22013-33-8) → 6-(4-[4-[18F]fluoro-3-hydroxybenzyl]piperazine-1-yl)benzodioxin (1350900-77-4)

Guidance literature:

Multi-step reaction with 3 steps

1: ethylene glycol / 150 °C / Inert atmosphere

2: sodium cyanoborohydride / dimethyl sulfoxide; acetic acid / 0.25 h / 110 °C

3: palladium; ammonium formate / methanol / 0.13 h / 60 °C / Inert atmosphere

With ammonium formate; sodium cyanoborohydride; palladium; In methanol; ethylene glycol; acetic acid; dimethyl sulfoxide;

DOI:10.1002/jlcr.3074

upstream raw materials:

3-benzyloxy-4-[¹⁸F]fluorobenzaldehyde

3-benzyloxy-4-N,N-dimethylaminobenzaldehyde

4-bromo-2-benzyloxy-N,N-dimethylaniline

3-Benzyloxy-4-nitro-benzaldehyde