(S)-methyl 4-((tert-butoxycarbonyl)amino)-6-phenylhex-5-enoate

Base Information

Chemical Name:(S)-methyl 4-((tert-butoxycarbonyl)amino)-6-phenylhex-5-enoate
CAS No.:1427516-72-0
Molecular Formula:C₁₈H₂₅NO₄
Molecular Weight:319.401
Hs Code.:

Synonyms:

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Chemical Property of (S)-methyl 4-((tert-butoxycarbonyl)amino)-6-phenylhex-5-enoate

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Technology Process of (S)-methyl 4-((tert-butoxycarbonyl)amino)-6-phenylhex-5-enoate

There total 9 articles about (S)-methyl 4-((tert-butoxycarbonyl)amino)-6-phenylhex-5-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₁H₁₆Cl₃NO₃

: 1427516-72-0
(S)-methyl 4-((tert-butoxycarbonyl)amino)-6-phenylhex-5-enoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: m-xylene / 8 h / Reflux; Inert atmosphere

2.1: potassium hydroxide / ethanol; water / 48 h / 100 °C

2.2: 24 h / 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

4.1: 4-methylmorpholine N-oxide; osmium(VIII) oxide / water; acetone / 5 h / 0 - 20 °C

5.1: sodium periodate / dichloromethane; water / 6 h / 0 - 20 °C

6.1: potassium carbonate; 18-crown-6 ether / dichloromethane / 12 h / Inert atmosphere; Reflux

With sodium periodate; osmium(VIII) oxide; 18-crown-6 ether; potassium carbonate; 4-methylmorpholine N-oxide; potassium hydroxide; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; m-xylene; acetone; 6.1: |Wittig Olefination;
DOI:10.1039/c3cc40824h

Reference yield:

: 1427516-53-7
(S,E)-ethyl 4-(2,2,2-trichloroacetamido)hept-5-enoate

: 1427516-72-0
(S)-methyl 4-((tert-butoxycarbonyl)amino)-6-phenylhex-5-enoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium hydroxide / ethanol; water / 48 h / 100 °C

1.2: 24 h / 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

3.1: 4-methylmorpholine N-oxide; osmium(VIII) oxide / water; acetone / 5 h / 0 - 20 °C

4.1: sodium periodate / dichloromethane; water / 6 h / 0 - 20 °C

5.1: potassium carbonate; 18-crown-6 ether / dichloromethane / 12 h / Inert atmosphere; Reflux

With sodium periodate; osmium(VIII) oxide; 18-crown-6 ether; potassium carbonate; 4-methylmorpholine N-oxide; potassium hydroxide; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; 5.1: |Wittig Olefination;
DOI:10.1039/c3cc40824h

Reference yield:

: 1427516-54-8
(S,E)-4-((tert-butoxycarbonyl)amino)hept-5-enoic acid

: 1427516-72-0
(S)-methyl 4-((tert-butoxycarbonyl)amino)-6-phenylhex-5-enoate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

2: 4-methylmorpholine N-oxide; osmium(VIII) oxide / water; acetone / 5 h / 0 - 20 °C

3: sodium periodate / dichloromethane; water / 6 h / 0 - 20 °C

4: potassium carbonate; 18-crown-6 ether / dichloromethane / 12 h / Inert atmosphere; Reflux

With sodium periodate; osmium(VIII) oxide; 18-crown-6 ether; potassium carbonate; 4-methylmorpholine N-oxide; In dichloromethane; water; N,N-dimethyl-formamide; acetone; 4: |Wittig Olefination;
DOI:10.1039/c3cc40824h