C₂₄H₂₁FN₂O₂

Base Information

• Chemical Name: C₂₄H₂₁FN₂O₂
• CAS No.: 1395923-32-6
• Molecular Formula: C₂₄H₂₁FN₂O₂
• Molecular Weight: 388.441
• Mol file: 1395923-32-6.mol

Synonyms:

Chemical Property of C₂₄H₂₁FN₂O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₄H₂₁FN₂O₂

There total 4 articles about C₂₄H₂₁FN₂O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(3-amino-phenyl)-4-fluoro-benzamide (304883-99-6) + 2-chloro-6,7,8,9-tetrahydro-5H-benzocycloheptene-5-one (24127-36-4) → C24H21FN2O2 (1395923-32-6)

Guidance literature:

With potassium tert-butylate; palladium diacetate; XPhos; In toluene; tert-butyl alcohol; at 90 ℃; Inert atmosphere;

DOI:10.1021/jm300951u

Reference yield:

5-(3-chlorophenyl)-pentanoic acid (625129-63-7) → C24H21FN2O2 (1395923-32-6)

Guidance literature:

Multi-step reaction with 3 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C / Inert atmosphere

2: aluminum (III) chloride / dichloromethane / 4 h / 20 °C

3: palladium diacetate; XPhos; potassium tert-butylate / tert-butyl alcohol; toluene / 90 °C / Inert atmosphere

With aluminum (III) chloride; oxalyl dichloride; potassium tert-butylate; palladium diacetate; N,N-dimethyl-formamide; XPhos; In dichloromethane; toluene; tert-butyl alcohol; 2: |Friedel-Crafts Acylation / 3: |Buchwald-Hartwig Coupling;

DOI:10.1021/jm300951u

Reference yield:

(3-carboxypropyl)triphenylphosphonium bromide → C24H21FN2O2 (1395923-32-6)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sodium methylate / methanol / 1 h / Reflux; Inert atmosphere

1.2: 6 h / Inert atmosphere

2.1: 10% Pd/C; hydrogen / ethyl acetate; acetonitrile / 5 h / 20 °C

3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C / Inert atmosphere

4.1: aluminum (III) chloride / dichloromethane / 4 h / 20 °C

5.1: palladium diacetate; XPhos; potassium tert-butylate / tert-butyl alcohol; toluene / 90 °C / Inert atmosphere

With aluminum (III) chloride; oxalyl dichloride; 10% Pd/C; potassium tert-butylate; hydrogen; sodium methylate; palladium diacetate; N,N-dimethyl-formamide; XPhos; In methanol; dichloromethane; ethyl acetate; toluene; acetonitrile; tert-butyl alcohol; 1.1: |Wittig Olefination / 1.2: |Wittig Olefination / 4.1: |Friedel-Crafts Acylation / 5.1: |Buchwald-Hartwig Coupling;

DOI:10.1021/jm300951u

upstream raw materials:

N-(3-amino-phenyl)-4-fluoro-benzamide

2-chloro-6,7,8,9-tetrahydro-5H-benzocycloheptene-5-one

5-(3-chlorophenyl)-pentanoic acid

Refernces