(5R,8R,9S,11R,13aS)-5-benzyl-9-(tert-butyldimethylsilyloxy)-8-methyl-11-((S)-1-methylallyl)-decahydro-12-oxa-3a,6-diaza-cyclopentacyclododecene-4,7,13-trione

Base Information

Chemical Name:(5R,8R,9S,11R,13aS)-5-benzyl-9-(tert-butyldimethylsilyloxy)-8-methyl-11-((S)-1-methylallyl)-decahydro-12-oxa-3a,6-diaza-cyclopentacyclododecene-4,7,13-trione
CAS No.:1258866-13-5
Molecular Formula:C₃₀H₄₆N₂O₅Si
Molecular Weight:542.791
Hs Code.:

(5R,8R,9S,11R,13aS)-5-benzyl-9-(tert-butyldimethylsilyloxy)-8-methyl-11-((S)-1-methylallyl)-decahydro-12-oxa-3a,6-diaza-cyclopentacyclododecene-4,7,13-trione

Synonyms:

Suppliers and Price of (5R,8R,9S,11R,13aS)-5-benzyl-9-(tert-butyldimethylsilyloxy)-8-methyl-11-((S)-1-methylallyl)-decahydro-12-oxa-3a,6-diaza-cyclopentacyclododecene-4,7,13-trione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (5R,8R,9S,11R,13aS)-5-benzyl-9-(tert-butyldimethylsilyloxy)-8-methyl-11-((S)-1-methylallyl)-decahydro-12-oxa-3a,6-diaza-cyclopentacyclododecene-4,7,13-trione

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (5R,8R,9S,11R,13aS)-5-benzyl-9-(tert-butyldimethylsilyloxy)-8-methyl-11-((S)-1-methylallyl)-decahydro-12-oxa-3a,6-diaza-cyclopentacyclododecene-4,7,13-trione

There total 13 articles about (5R,8R,9S,11R,13aS)-5-benzyl-9-(tert-butyldimethylsilyloxy)-8-methyl-11-((S)-1-methylallyl)-decahydro-12-oxa-3a,6-diaza-cyclopentacyclododecene-4,7,13-trione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₀H₄₈N₂O₆Si

: 1258866-13-5
(5R,8R,9S,11R,13aS)-5-benzyl-9-(tert-butyldimethylsilyloxy)-8-methyl-11-((S)-1-methylallyl)-decahydro-12-oxa-3a,6-diaza-cyclopentacyclododecene-4,7,13-trione

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 3h; Inert atmosphere;
DOI:10.1021/jo1017487

Reference yield:

: 1258866-19-1
(5S,6S)-5-allyl-2,2,3,3,6,9,9,10,10-nonamethyl-4,8-dioxa-3,9-disilaundecane

: 1258866-13-5
(5R,8R,9S,11R,13aS)-5-benzyl-9-(tert-butyldimethylsilyloxy)-8-methyl-11-((S)-1-methylallyl)-decahydro-12-oxa-3a,6-diaza-cyclopentacyclododecene-4,7,13-trione

Guidance literature:: Multi-step reaction with 8 steps

1.1: 2,6-dimethylpyridine; sodium periodate; osmium(VIII) oxide / 1,4-dioxane; water / 3.5 h / 20 °C / Inert atmosphere

2.1: diethyl ether / 4 h / -78 °C / Inert atmosphere

3.1: dmap; 2,4,6-trichlorobenzoyl chloride; N-ethyl-N,N-diisopropylamine / toluene / 8 h / -78 - 20 °C / Inert atmosphere

4.1: zinc dibromide / dichloromethane / 4 h / 20 °C / Inert atmosphere

4.2: Inert atmosphere

5.1: sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; potassium bromide / dichloromethane; water / 0.5 h / 0 °C / Inert atmosphere

6.1: sodium dihydrogenphosphate; sodium chlorite; 2-methyl-but-2-ene / water; tert-butyl alcohol / 0.5 h / 0 - 20 °C / Inert atmosphere

7.1: diethylamine / acetonitrile / 20 °C / Inert atmosphere

8.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

With 2,6-dimethylpyridine; dmap; sodium hypochlorite; sodium chlorite; sodium periodate; sodium dihydrogenphosphate; osmium(VIII) oxide; 2-methyl-but-2-ene; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; 2,4,6-trichlorobenzoyl chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diethylamine; N-ethyl-N,N-diisopropylamine; potassium bromide; zinc dibromide; In 1,4-dioxane; diethyl ether; dichloromethane; water; toluene; acetonitrile; tert-butyl alcohol;
DOI:10.1021/jo1017487

Reference yield:

: C₁₈H₄₀O₃Si₂

: 1258866-13-5
(5R,8R,9S,11R,13aS)-5-benzyl-9-(tert-butyldimethylsilyloxy)-8-methyl-11-((S)-1-methylallyl)-decahydro-12-oxa-3a,6-diaza-cyclopentacyclododecene-4,7,13-trione

Guidance literature:: Multi-step reaction with 7 steps

1.1: diethyl ether / 4 h / -78 °C / Inert atmosphere

2.1: dmap; 2,4,6-trichlorobenzoyl chloride; N-ethyl-N,N-diisopropylamine / toluene / 8 h / -78 - 20 °C / Inert atmosphere

3.1: zinc dibromide / dichloromethane / 4 h / 20 °C / Inert atmosphere

3.2: Inert atmosphere

4.1: sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; potassium bromide / dichloromethane; water / 0.5 h / 0 °C / Inert atmosphere

5.1: sodium dihydrogenphosphate; sodium chlorite; 2-methyl-but-2-ene / water; tert-butyl alcohol / 0.5 h / 0 - 20 °C / Inert atmosphere

6.1: diethylamine / acetonitrile / 20 °C / Inert atmosphere

7.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

With dmap; sodium hypochlorite; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; 2,4,6-trichlorobenzoyl chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diethylamine; N-ethyl-N,N-diisopropylamine; potassium bromide; zinc dibromide; In diethyl ether; dichloromethane; water; toluene; acetonitrile; tert-butyl alcohol;
DOI:10.1021/jo1017487