4-Amino-1-[(2R,3R,4S,5R)-5-(tert-butyl-diphenyl-silanyloxymethyl)-3,4-dihydroxy-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidine-5-carbaldehyde

Base Information

Chemical Name:4-Amino-1-[(2R,3R,4S,5R)-5-(tert-butyl-diphenyl-silanyloxymethyl)-3,4-dihydroxy-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidine-5-carbaldehyde
CAS No.:329897-77-0
Molecular Formula:C₂₆H₃₁N₃O₆Si
Molecular Weight:509.634
Hs Code.:

4-Amino-1-[(2R,3R,4S,5R)-5-(tert-butyl-diphenyl-silanyloxymethyl)-3,4-dihydroxy-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidine-5-carbaldehyde

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Chemical Property of 4-Amino-1-[(2R,3R,4S,5R)-5-(tert-butyl-diphenyl-silanyloxymethyl)-3,4-dihydroxy-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidine-5-carbaldehyde

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Technology Process of 4-Amino-1-[(2R,3R,4S,5R)-5-(tert-butyl-diphenyl-silanyloxymethyl)-3,4-dihydroxy-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidine-5-carbaldehyde

There total 10 articles about 4-Amino-1-[(2R,3R,4S,5R)-5-(tert-butyl-diphenyl-silanyloxymethyl)-3,4-dihydroxy-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidine-5-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 329897-75-8
4-amino-1-[5-(tert-butyl-diphenyl-silanyloxymethyl)-3,4-dihydroxy-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidin-2-one

: 329897-77-0
4-Amino-1-[(2R,3R,4S,5R)-5-(tert-butyl-diphenyl-silanyloxymethyl)-3,4-dihydroxy-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidine-5-carbaldehyde

: 329897-76-9
4-amino-1-[5-(tert-butyl-diphenyl-silanyloxymethyl)-3,4-dihydroxy-tetrahydro-furan-2-yl]-5-hydroxymethyl-1H-pyrimidin-2-one

Guidance literature:: With sodium persulfate; at 70 ℃; pH=7;
DOI:10.1016/S0040-4039(00)02191-2

Reference yield:

: 6974-32-9
1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose

: 329897-77-0
4-Amino-1-[(2R,3R,4S,5R)-5-(tert-butyl-diphenyl-silanyloxymethyl)-3,4-dihydroxy-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidine-5-carbaldehyde

Guidance literature:: Multi-step reaction with 7 steps

1: SnCl₄

2: NaHCO₃ / H₂O

3: 98 percent / Et₃N; POCl₃ / acetonitrile

4: NH₃ / dioxane / 24 h / 20 °C

5: NH₃ / methanol

6: 94 percent / imidazole / dimethylformamide

7: 20 percent / Na₂S₂O₈ / 70 °C / pH 7

With 1H-imidazole; sodium persulfate; ammonia; tin(IV) chloride; sodium hydrogencarbonate; triethylamine; trichlorophosphate; In 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/S0040-4039(00)02191-2

Reference yield:

: 3180-76-5
2',3',5'-tri-O-benzoyluridine

: 329897-77-0
4-Amino-1-[(2R,3R,4S,5R)-5-(tert-butyl-diphenyl-silanyloxymethyl)-3,4-dihydroxy-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidine-5-carbaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1: 98 percent / Et₃N; POCl₃ / acetonitrile

2: NH₃ / dioxane / 24 h / 20 °C

3: NH₃ / methanol

4: 94 percent / imidazole / dimethylformamide

5: 20 percent / Na₂S₂O₈ / 70 °C / pH 7

With 1H-imidazole; sodium persulfate; ammonia; triethylamine; trichlorophosphate; In 1,4-dioxane; methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/S0040-4039(00)02191-2