Technology Process of C22H17F4NO5
There total 4 articles about C22H17F4NO5 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: trifluoroacetic acid; triethylsilane / dichloromethane / 0 - 20 °C
2: triethylamine / dichloromethane / 2 h / 0 °C
3: water; ytterbium(III) triflate / tetrahydrofuran / 48 h / 20 °C
With
triethylsilane; water; triethylamine; trifluoroacetic acid; ytterbium(III) triflate;
In
tetrahydrofuran; dichloromethane;
2: |Mukaiyama Aldol Addition;
DOI:10.1007/s00044-012-0180-1
- Guidance literature:
-
Multi-step reaction with 2 steps
1: triethylamine / dichloromethane / 2 h / 0 °C
2: water; ytterbium(III) triflate / tetrahydrofuran / 48 h / 20 °C
With
water; triethylamine; ytterbium(III) triflate;
In
tetrahydrofuran; dichloromethane;
1: |Mukaiyama Aldol Addition;
DOI:10.1007/s00044-012-0180-1
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: isopropylmagnesium chloride / tetrahydrofuran / 0.5 h / 0 °C
1.2: 0 - 20 °C
2.1: trifluoroacetic acid; triethylsilane / dichloromethane / 0 - 20 °C
3.1: triethylamine / dichloromethane / 2 h / 0 °C
4.1: water; ytterbium(III) triflate / tetrahydrofuran / 48 h / 20 °C
With
triethylsilane; water; isopropylmagnesium chloride; triethylamine; trifluoroacetic acid; ytterbium(III) triflate;
In
tetrahydrofuran; dichloromethane;
3.1: |Mukaiyama Aldol Addition;
DOI:10.1007/s00044-012-0180-1