9-Boc-2,2-difluoro-1-oxa-4,9-diazaspiro[5.5]undecane

Base Information

• Chemical Name: 9-Boc-2,2-difluoro-1-oxa-4,9-diazaspiro[5.5]undecane
• CAS No.: 1179337-15-5
• Molecular Formula: C₁₃H₂₂F₂N₂O₃
• Molecular Weight: 292.326
• Mol file: 1179337-15-5.mol

Synonyms:

Chemical Property of 9-Boc-2,2-difluoro-1-oxa-4,9-diazaspiro[5.5]undecane

Chemical Property:

• Storage Temp.: 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

tert-butyl2,2-difluoro-1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylate 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 9-Boc-2,2-difluoro-1-oxa-4,9-diazaspiro[5.5]undecane

There total 3 articles about 9-Boc-2,2-difluoro-1-oxa-4,9-diazaspiro[5.5]undecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 10,10-difluoro-9-oxo-11-oxa-3,8-diazaspiro[5.5]undecane-3-carboxylate (1179337-14-4) → tert-butyl 10,10-difluoro-11-oxa-3,8-diazaspiro[5.5]undecane-3-carboxylate (1179337-15-5)

Guidance literature:

tert-butyl 10,10-difluoro-9-oxo-11-oxa-3,8-diazaspiro[5.5]undecane-3-carboxylate; With dimethylsulfide borane complex; In tetrahydrofuran; at 55 ℃; for 2h;

With N,N`-dimethylethylenediamine; In tetrahydrofuran; methanol; at 70 ℃; for 0.666667h;

Reference yield:

4-aminomethyl-4-hydroxypiperidine-1-carboxylic acid tert-butyl ester (392331-66-7) → tert-butyl 10,10-difluoro-11-oxa-3,8-diazaspiro[5.5]undecane-3-carboxylate (1179337-15-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: N,N-dimethyl-formamide / 1 h / Inert atmosphere

2.1: potassium tert-butylate / tetrahydrofuran / 0.58 h / 70 °C

3.1: dimethylsulfide borane complex / tetrahydrofuran / 2 h / 55 °C

3.2: 0.67 h / 70 °C

With dimethylsulfide borane complex; potassium tert-butylate; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

tert-butyl 4-[[(2-bromo-2,2-difluoro-acetyl)amino]methyl]-4-hydroxy-piperidine-1-carboxylate (1179337-13-3) → tert-butyl 10,10-difluoro-11-oxa-3,8-diazaspiro[5.5]undecane-3-carboxylate (1179337-15-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium tert-butylate / tetrahydrofuran / 0.58 h / 70 °C

2.1: dimethylsulfide borane complex / tetrahydrofuran / 2 h / 55 °C

2.2: 0.67 h / 70 °C

With dimethylsulfide borane complex; potassium tert-butylate; In tetrahydrofuran;

upstream raw materials:

4-aminomethyl-4-hydroxypiperidine-1-carboxylic acid tert-butyl ester

tert-butyl 4-[[(2-bromo-2,2-difluoro-acetyl)amino]methyl]-4-hydroxy-piperidine-1-carboxylate

tert-butyl 10,10-difluoro-9-oxo-11-oxa-3,8-diazaspiro[5.5]undecane-3-carboxylate