oestrone acetate

Base Information

• Chemical Name: oestrone acetate
• CAS No.: 57605-53-5
• Molecular Formula: C₂₀H₂₄O₃
• Molecular Weight: 312.409
• Mol file: 57605-53-5.mol

Synonyms:

Chemical Property of oestrone acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of oestrone acetate

There total 14 articles about oestrone acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

estrone (53-16-7,474-84-0,517-06-6,1225-03-2,4413-09-6,4680-83-5,5285-27-8,15426-98-9,17337-44-9,19973-76-3,35937-97-4,35937-99-6,35938-00-2,94424-34-7,101976-76-5,107910-81-6) + acetic anhydride (108-24-7) → oestrone acetate (901-93-9,21610-87-7,34990-86-8,57605-53-5,57605-54-6,57605-55-7)

Guidance literature:

With pyridine; for 2h; Heating;

DOI:10.1016/S0040-4020(01)89772-6

Reference yield: 89.0%

1-acetyl-1H-1,2,3-triazolo<4,5-b>pyridine (107866-54-6) + estrone (53-16-7,474-84-0,517-06-6,1225-03-2,4413-09-6,4680-83-5,5285-27-8,15426-98-9,17337-44-9,19973-76-3,35937-97-4,35937-99-6,35938-00-2,94424-34-7,101976-76-5,107910-81-6) → estrone acetate (901-93-9,21610-87-7,34990-86-8,57605-53-5,57605-54-6,57605-55-7)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; for 24h; Ambient temperature;

Reference yield:

→ oestrone acetate (901-93-9,21610-87-7,34990-86-8,57605-53-5,57605-54-6,57605-55-7) + 16β-bromoestrone (1228-71-3,71765-95-2,95340-34-4)

Guidance literature:

With hydrogen bromide; bromine; potassium carbonate; Yield given. Multistep reaction; 1) CHCl₃, CH₃COOH, room temp., 20 min; 2) water, room temp., 3 h.;

DOI:10.1007/BF00575701

upstream raw materials:

estrone

acetic anhydride

1-acetyl-1H-1,2,3-triazolo<4,5-b>pyridine

estrone

Downstream raw materials:

16-Oxo-oestradiol-(17β)

16α-Hydroxy-oestron

16α-bromoestrone

16β-bromoestrone