Technology Process of CDM-NAG
There total 4 articles about CDM-NAG which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
In
tert-butyl methyl ether; Isopropyl acetate; N,N-dimethyl-formamide;
at 0 ℃;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: trifluorormethanesulfonic acid / dichloromethane / 20 °C / Inert atmosphere; Reflux
2.1: potassium carbonate; methanol / 7 h / 20 °C / Inert atmosphere
2.2: Amberlyst 15 acidic resin / 0.5 h / 20 °C
3.1: hydrogen / palladium-on-charcoal / 2,2,2-trifluoroethanol / 5 h / 20 °C
4.1: N,N-dimethyl-formamide; tert-butyl methyl ether; Isopropyl acetate / 0 °C
With
methanol; trifluorormethanesulfonic acid; hydrogen; potassium carbonate;
palladium-on-charcoal;
In
dichloromethane; tert-butyl methyl ether; 2,2,2-trifluoroethanol; Isopropyl acetate; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: hydrogen / palladium-on-charcoal / 2,2,2-trifluoroethanol / 5 h / 20 °C
2: N,N-dimethyl-formamide; tert-butyl methyl ether; Isopropyl acetate / 0 °C
With
hydrogen;
palladium-on-charcoal;
In
tert-butyl methyl ether; 2,2,2-trifluoroethanol; Isopropyl acetate; N,N-dimethyl-formamide;