Technology Process of [6-[benzoyl(methyl)amino]-5-methyl-3-pyridyl]boronic acid
There total 3 articles about [6-[benzoyl(methyl)amino]-5-methyl-3-pyridyl]boronic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Triisopropyl borate; N-(5-bromo-3-methylpyridin-2-yl)-N-methylbenzamide;
With
n-butyllithium;
In
tetrahydrofuran;
at -75 - -70 ℃;
for 4h;
Inert atmosphere;
water;
In
tetrahydrofuran;
at -20 - 35 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydroxide / 25 - 35 °C
2.1: sodium tetrahydroborate / tetrahydrofuran / 1 h / 25 - 35 °C
2.2: 5 h / Reflux
3.1: n-butyllithium / tetrahydrofuran / 4 h / -75 - -70 °C / Inert atmosphere
3.2: 1 h / -20 - 35 °C
With
sodium tetrahydroborate; n-butyllithium; sodium hydroxide;
In
tetrahydrofuran;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium tetrahydroborate / tetrahydrofuran / 1 h / 25 - 35 °C
1.2: 5 h / Reflux
2.1: n-butyllithium / tetrahydrofuran / 4 h / -75 - -70 °C / Inert atmosphere
2.2: 1 h / -20 - 35 °C
With
sodium tetrahydroborate; n-butyllithium;
In
tetrahydrofuran;
