Technology Process of 3,5-di-iodo-4'-O-methyl-3'-<(6-methylpyridin-3-yl)methyl>-N-trifluoroacetyl-L-thyronine ethyl ester
There total 7 articles about 3,5-di-iodo-4'-O-methyl-3'-<(6-methylpyridin-3-yl)methyl>-N-trifluoroacetyl-L-thyronine ethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 61 percent / butyl-lithium / hexane / THF, -90 deg C, -80 deg C, 10min , RT
2: pyridine / 100 °C
3: 64 percent / H2 / 10percent Pd/C / acetic acid; H2O / 1.5 h
4: 54 percent / methanesulphonyl chloride / pyridine / 1.17 h / Heating
5: H2 / 10percent Pd/C / acetic acid / 1 h / 2585.7 Torr
6: 1.) sulphuric acid, sodium nitrite, 2.) potassium iodide,iodine, urea / 1.) water, -10 deg C, 2.) chloroform, water, RT, 1-2 h
With
pyridine; n-butyllithium; sulfuric acid; hydrogen; iodine; methanesulfonyl chloride; urea; potassium iodide; sodium nitrite;
palladium on activated charcoal;
In
pyridine; hexane; water; acetic acid;
DOI:10.1039/P19880003085
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 61 percent / butyl-lithium / hexane / THF, -90 deg C, -80 deg C, 10min , RT
2: pyridine / 100 °C
3: 64 percent / H2 / 10percent Pd/C / acetic acid; H2O / 1.5 h
4: 54 percent / methanesulphonyl chloride / pyridine / 1.17 h / Heating
5: H2 / 10percent Pd/C / acetic acid / 1 h / 2585.7 Torr
6: 1.) sulphuric acid, sodium nitrite, 2.) potassium iodide,iodine, urea / 1.) water, -10 deg C, 2.) chloroform, water, RT, 1-2 h
With
pyridine; n-butyllithium; sulfuric acid; hydrogen; iodine; methanesulfonyl chloride; urea; potassium iodide; sodium nitrite;
palladium on activated charcoal;
In
pyridine; hexane; water; acetic acid;
DOI:10.1039/P19880003085
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 54 percent / methanesulphonyl chloride / pyridine / 1.17 h / Heating
2: H2 / 10percent Pd/C / acetic acid / 1 h / 2585.7 Torr
3: 1.) sulphuric acid, sodium nitrite, 2.) potassium iodide,iodine, urea / 1.) water, -10 deg C, 2.) chloroform, water, RT, 1-2 h
With
sulfuric acid; hydrogen; iodine; methanesulfonyl chloride; urea; potassium iodide; sodium nitrite;
palladium on activated charcoal;
In
pyridine; acetic acid;
DOI:10.1039/P19880003085
