prolyl-p-(γ-aminobutyryloamino)phenylalanyl-glycinamide dihydrochloride

Base Information

Chemical Name:prolyl-p-(γ-aminobutyryloamino)phenylalanyl-glycinamide dihydrochloride
CAS No.:132177-79-8
Molecular Formula:C₂₀H₃₀N₆O₄*2ClH
Molecular Weight:491.418
Hs Code.:

Synonyms:

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Chemical Property of prolyl-p-(γ-aminobutyryloamino)phenylalanyl-glycinamide dihydrochloride

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Technology Process of prolyl-p-(γ-aminobutyryloamino)phenylalanyl-glycinamide dihydrochloride

There total 6 articles about prolyl-p-(γ-aminobutyryloamino)phenylalanyl-glycinamide dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 15761-39-4,59433-50-0
1-(tert-butoxycarbonyl)-L-proline

: 132177-79-8
prolyl-p-(γ-aminobutyryloamino)phenylalanyl-glycinamide dihydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) N-hydroxysuccinimide, N,N-dicyclohexylocarbodiimide (DDCI), 2.) 15-crown-5, 1 M aq. KOH / 1.) DMF, 2h, 2.) DMF, 16 h

2: 75 percent / N-hydroxysuccinimide, N,N-dicyclohexylcarbodiimide, triethylamine / dimethylformamide / 16 h

3: H₂ / 10percent Pd/C / methanol

4: N-hydroxysuccinimide, N,N-dicyclohexylocarbodiimide (DCC) / ethyl acetate / 24 h / -10 °C

5: NH₃ gas / methanol / 72 h / Ambient temperature

6: 4 M HCl / dioxane

With hydrogenchloride; potassium hydroxide; 1-hydroxy-pyrrolidine-2,5-dione; 15-crown-5; ammonia; hydrogen; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In 1,4-dioxane; methanol; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 949-99-5
4-nitro-3-phenyl-L-alanine

: 132177-79-8
prolyl-p-(γ-aminobutyryloamino)phenylalanyl-glycinamide dihydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) N-hydroxysuccinimide, N,N-dicyclohexylocarbodiimide (DDCI), 2.) 15-crown-5, 1 M aq. KOH / 1.) DMF, 2h, 2.) DMF, 16 h

2: 75 percent / N-hydroxysuccinimide, N,N-dicyclohexylcarbodiimide, triethylamine / dimethylformamide / 16 h

3: H₂ / 10percent Pd/C / methanol

4: N-hydroxysuccinimide, N,N-dicyclohexylocarbodiimide (DCC) / ethyl acetate / 24 h / -10 °C

5: NH₃ gas / methanol / 72 h / Ambient temperature

6: 4 M HCl / dioxane

With hydrogenchloride; potassium hydroxide; 1-hydroxy-pyrrolidine-2,5-dione; 15-crown-5; ammonia; hydrogen; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In 1,4-dioxane; methanol; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 132149-56-5
N-t-butyloxycarbonylprolyl-p-nitrophenylalanine

: 132177-79-8
prolyl-p-(γ-aminobutyryloamino)phenylalanyl-glycinamide dihydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: 75 percent / N-hydroxysuccinimide, N,N-dicyclohexylcarbodiimide, triethylamine / dimethylformamide / 16 h

2: H₂ / 10percent Pd/C / methanol

3: N-hydroxysuccinimide, N,N-dicyclohexylocarbodiimide (DCC) / ethyl acetate / 24 h / -10 °C

4: NH₃ gas / methanol / 72 h / Ambient temperature

5: 4 M HCl / dioxane

With hydrogenchloride; 1-hydroxy-pyrrolidine-2,5-dione; ammonia; hydrogen; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In 1,4-dioxane; methanol; ethyl acetate; N,N-dimethyl-formamide;