(5R)-3,6-cyclo-4-nor-3,5-seco-6β-androstane-3α,5,17β-triol 3-acetate 17-propionate 5-thiobenzoate

Base Information

Chemical Name:(5R)-3,6-cyclo-4-nor-3,5-seco-6β-androstane-3α,5,17β-triol 3-acetate 17-propionate 5-thiobenzoate
CAS No.:133123-18-9
Molecular Formula:C₃₀H₄₀O₅S
Molecular Weight:512.711
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (5R)-3,6-cyclo-4-nor-3,5-seco-6β-androstane-3α,5,17β-triol 3-acetate 17-propionate 5-thiobenzoate

Chemical Property:

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Technology Process of (5R)-3,6-cyclo-4-nor-3,5-seco-6β-androstane-3α,5,17β-triol 3-acetate 17-propionate 5-thiobenzoate

There total 6 articles about (5R)-3,6-cyclo-4-nor-3,5-seco-6β-androstane-3α,5,17β-triol 3-acetate 17-propionate 5-thiobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 57-85-2
testosterone propionate

: 133123-18-9
(5R)-3,6-cyclo-4-nor-3,5-seco-6β-androstane-3α,5,17β-triol 3-acetate 17-propionate 5-thiobenzoate

Guidance literature:: Multi-step reaction with 6 steps

1: 94 percent / K₂CO₃, KMnO₄, NaIO₄ / 2-methyl-propan-2-ol; H₂O / 4.5 h / Ambient temperature

2: 95 percent / 80percent aq. HClO₄, acetic anhydride / ethyl acetate / 0.17 h

3: 18 percent / lithium tri-t-butoxyaluminium hydride / tetrahydrofuran / -80 deg C up to 0 deg C, 1 h

4: 95 percent / pyridine / Ambient temperature

5: 95 percent / NaBH₄ / ethanol; ethyl acetate / 20 h / -5 °C / or lithium tri-t-butoxyaluminium hydride, THF, room temp., 20 h

With pyridine; sodium tetrahydroborate; potassium permanganate; sodium periodate; perchloric acid; lithium tri(t-butoxy)aluminum hydride; acetic anhydride; potassium carbonate; In tetrahydrofuran; ethanol; water; ethyl acetate; tert-butyl alcohol;

Reference yield:

: 3510-18-7
5-oxo-17β-propionyloxy-4-nor-3,5-secoandrostan-3-oic acid

: 133123-18-9
(5R)-3,6-cyclo-4-nor-3,5-seco-6β-androstane-3α,5,17β-triol 3-acetate 17-propionate 5-thiobenzoate

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / 80percent aq. HClO₄, acetic anhydride / ethyl acetate / 0.17 h

2: 18 percent / lithium tri-t-butoxyaluminium hydride / tetrahydrofuran / -80 deg C up to 0 deg C, 1 h

3: 95 percent / pyridine / Ambient temperature

4: 95 percent / NaBH₄ / ethanol; ethyl acetate / 20 h / -5 °C / or lithium tri-t-butoxyaluminium hydride, THF, room temp., 20 h

With pyridine; sodium tetrahydroborate; perchloric acid; lithium tri(t-butoxy)aluminum hydride; acetic anhydride; In tetrahydrofuran; ethanol; ethyl acetate;

Reference yield:

: 3510-19-8
17β-propionyloxy-4-oxaandrost-5-en-3-one

: 133123-18-9
(5R)-3,6-cyclo-4-nor-3,5-seco-6β-androstane-3α,5,17β-triol 3-acetate 17-propionate 5-thiobenzoate

Guidance literature:: Multi-step reaction with 4 steps

1: 18 percent / lithium tri-t-butoxyaluminium hydride / tetrahydrofuran / -80 deg C up to 0 deg C, 1 h

2: 95 percent / pyridine / Ambient temperature

3: 95 percent / NaBH₄ / ethanol; ethyl acetate / 20 h / -5 °C / or lithium tri-t-butoxyaluminium hydride, THF, room temp., 20 h

With pyridine; sodium tetrahydroborate; lithium tri(t-butoxy)aluminum hydride; In tetrahydrofuran; ethanol; ethyl acetate;