Technology Process of 2α-phenylseleno-11-hydroxy-4β,5α-eudesm-3-one
There total 7 articles about 2α-phenylseleno-11-hydroxy-4β,5α-eudesm-3-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 100 mg / Jones reagent / acetone / 0.5 h / Ambient temperature
2: 5percent KOH / methanol / 6 h / Heating
3: 1.) lithium diisopropylamide (LDA), hexamethylphosphoric triamide (HMPA) / 1.) THF, -78 deg C, 1 h, 2.) THF, -78 deg C
With
N,N,N,N,N,N-hexamethylphosphoric triamide; potassium hydroxide; jones reagent; lithium diisopropyl amide;
In
methanol; acetone;
DOI:10.1246/bcsj.55.1191
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 5percent KOH / methanol / 6 h / Heating
2: 1.) lithium diisopropylamide (LDA), hexamethylphosphoric triamide (HMPA) / 1.) THF, -78 deg C, 1 h, 2.) THF, -78 deg C
With
N,N,N,N,N,N-hexamethylphosphoric triamide; potassium hydroxide; lithium diisopropyl amide;
In
methanol;
DOI:10.1246/bcsj.55.1191
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 340 mg / liq. NH3, lithium / diethyl ether / 1 h / -78 °C
2: 1.) mercury(II) acetate, 2.) 3 M NaOH, sodium borohydride / 1.) THF, water, 0 deg C, 5 min., 2.) THF
3: 1.) lithium diisopropylamide (LDA), hexamethylphosphoric triamide (HMPA) / 1.) THF, -78 deg C, 1 h, 2.) THF, -78 deg C
With
N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hydroxide; sodium tetrahydroborate; mercury(II) diacetate; ammonia; lithium; lithium diisopropyl amide;
In
diethyl ether;
DOI:10.1246/bcsj.55.1191
