2-bromo-6-fluoro-3-methoxybenzaldehyde

Base Information

• Chemical Name: 2-bromo-6-fluoro-3-methoxybenzaldehyde
• CAS No.: 154650-22-3
• Molecular Formula: C₈H₆BrFO₂
• Molecular Weight: 233.037
• Hs Code.: 2913000090
• Mol file: 154650-22-3.mol

Synonyms:

Chemical Property of 2-bromo-6-fluoro-3-methoxybenzaldehyde

Chemical Property:

• Boiling Point: 286.8±35.0 °C(Predicted)
• Density: 1.601±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

2-Bromo-6-fluoro-3-methoxybenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-bromo-6-fluoro-3-methoxybenzaldehyde

There total 1 articles about 2-bromo-6-fluoro-3-methoxybenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.2%

2-bromo-4-fluoro-1-methoxybenzene (452-08-4) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 2-bromo-6-fluoro-3-methoxybenzaldehyde (154650-22-3)

Guidance literature:

2-bromo-4-fluoro-1-methoxybenzene; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

N,N-dimethyl-formamide; In tetrahydrofuran; at -65 ℃; for 1h; Reagent/catalyst; Inert atmosphere;

Reference yield: 92.3%

2-bromo-6-fluoro-3-methoxybenzaldehyde (154650-22-3) → 2-bromo-6-fluoro-3-hydroxybenzaldehyde

Guidance literature:

With methanol; palladium on activated charcoal; at 0 - 20 ℃; for 16h; Reagent/catalyst; Inert atmosphere;

Reference yield: 60.0%

2-bromo-6-fluoro-3-methoxybenzaldehyde (154650-22-3) → 2-bromo-6-fluoro-3-methoxybenzoic acid

Guidance literature:

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; In tetrahydrofuran; water; butan-1-ol; at 0 - 20 ℃; for 16h;

upstream raw materials:

2-bromo-4-fluoro-1-methoxybenzene

N,N-dimethyl-formamide

Refernces

• 1、 -. "Preparation method of imidazoline pyridine compound intermediate". Paragraph 0085-0091; 0139-0144; 0184-0189; 0229-0234; .... . Retrieved 2021/07/01.
• 2、 -. "MACROCYCLIC AZOLOPYRIDINE DERIVATIVES AS EED AND PRC2 MODULATORS". Paragraph 0777. . Retrieved 2020/10/09.