C₁₅H₁₁FN₂O₃

Base Information

• Chemical Name: C₁₅H₁₁FN₂O₃
• CAS No.: 1332325-45-7
• Molecular Formula: C₁₅H₁₁FN₂O₃
• Molecular Weight: 286.262
• Mol file: 1332325-45-7.mol

Synonyms:

Chemical Property of C₁₅H₁₁FN₂O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₅H₁₁FN₂O₃

There total 5 articles about C₁₅H₁₁FN₂O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C17H15FN2O3 (1332325-46-8) → C15H11FN2O3 (1332325-45-7)

Guidance literature:

With aluminum tri-bromide; In acetonitrile; at 0 ℃; for 8h;

DOI:10.1016/j.bmc.2011.06.058

Reference yield:

5-amino-N-(4-fluorobenzyl)-2,3-dimethoxybenzamide (1332325-43-5) → C15H11FN2O3 (1332325-45-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium nitrite / ethanol; water / -15 °C

1.2: 20 - 50 °C

2.1: aluminum tri-bromide / acetonitrile / 8 h / 0 °C

With aluminum tri-bromide; sodium nitrite; In ethanol; water; acetonitrile;

DOI:10.1016/j.bmc.2011.06.058

Reference yield:

2,3-dimethoxybenzoic acid (1521-38-6) → C15H11FN2O3 (1332325-45-7)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sulfuric acid; nitric acid / 1 h / 0 °C

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 6.5 h / 20 °C / Inert atmosphere

3.1: hydrogenchloride; tin(ll) chloride / tetrahydrofuran; water / 8 h / 20 °C

4.1: sodium nitrite / ethanol; water / -15 °C

4.2: 20 - 50 °C

5.1: aluminum tri-bromide / acetonitrile / 8 h / 0 °C

With hydrogenchloride; aluminum tri-bromide; sulfuric acid; nitric acid; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; tin(ll) chloride; sodium nitrite; In tetrahydrofuran; ethanol; water; acetonitrile;

DOI:10.1016/j.bmc.2011.06.058

upstream raw materials:

C₁₇H₁₅FN₂O₃

N-(4-fluorobenzyl)-2,3-dimethoxy-5-nitrobenzamide

5-amino-N-(4-fluorobenzyl)-2,3-dimethoxybenzamide

2,3-dimethoxybenzoic acid