(S)-2-[(1S,2R)-2-tert-butyldiphenylsilyloxy-1-methyl-3-butenyloxycarbonyl]-1-methylethyl (2E,4R,5S)-5-{N-acryloyl-(E)-[2-methyl-3-(2-methyl-4-thiazolyl)allyl]amino}-4-(2-methoxyethoxy)methoxy-2-hexenoate

Base Information

Chemical Name:(S)-2-[(1S,2R)-2-tert-butyldiphenylsilyloxy-1-methyl-3-butenyloxycarbonyl]-1-methylethyl (2E,4R,5S)-5-{N-acryloyl-(E)-[2-methyl-3-(2-methyl-4-thiazolyl)allyl]amino}-4-(2-methoxyethoxy)methoxy-2-hexenoate
CAS No.:1335287-06-3
Molecular Formula:C₄₆H₆₂N₂O₉SSi
Molecular Weight:847.158
Hs Code.:

(S)-2-[(1S,2R)-2-tert-butyldiphenylsilyloxy-1-methyl-3-butenyloxycarbonyl]-1-methylethyl (2E,4R,5S)-5-{N-acryloyl-(E)-[2-methyl-3-(2-methyl-4-thiazolyl)allyl]amino}-4-(2-methoxyethoxy)methoxy-2-hexenoate

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Chemical Property of (S)-2-[(1S,2R)-2-tert-butyldiphenylsilyloxy-1-methyl-3-butenyloxycarbonyl]-1-methylethyl (2E,4R,5S)-5-{N-acryloyl-(E)-[2-methyl-3-(2-methyl-4-thiazolyl)allyl]amino}-4-(2-methoxyethoxy)methoxy-2-hexenoate

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Technology Process of (S)-2-[(1S,2R)-2-tert-butyldiphenylsilyloxy-1-methyl-3-butenyloxycarbonyl]-1-methylethyl (2E,4R,5S)-5-{N-acryloyl-(E)-[2-methyl-3-(2-methyl-4-thiazolyl)allyl]amino}-4-(2-methoxyethoxy)methoxy-2-hexenoate

There total 14 articles about (S)-2-[(1S,2R)-2-tert-butyldiphenylsilyloxy-1-methyl-3-butenyloxycarbonyl]-1-methylethyl (2E,4R,5S)-5-{N-acryloyl-(E)-[2-methyl-3-(2-methyl-4-thiazolyl)allyl]amino}-4-(2-methoxyethoxy)methoxy-2-hexenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1174412-62-4
(3R,4S)-4-tert-butyldimethylsilyloxy-3-tert-butyldiphenylsilyloxy-1-pentene

: 1335287-06-3
(S)-2-[(1S,2R)-2-tert-butyldiphenylsilyloxy-1-methyl-3-butenyloxycarbonyl]-1-methylethyl (2E,4R,5S)-5-{N-acryloyl-(E)-[2-methyl-3-(2-methyl-4-thiazolyl)allyl]amino}-4-(2-methoxyethoxy)methoxy-2-hexenoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: water; acetic acid / tetrahydrofuran / Inert atmosphere

2.1: dmap / toluene / 1 h / 20 °C / Inert atmosphere

3.1: water; acetic acid / tetrahydrofuran / Inert atmosphere

4.1: dmap / toluene / 1 h / 20 °C / Inert atmosphere

5.1: trifluoroacetic acid / dichloromethane / 0.25 h / 0 °C / Inert atmosphere

5.2: Inert atmosphere; Saturated solution

6.1: 2-picoline borane complex; acetic acid / methanol / 0 - 20 °C / Inert atmosphere

7.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 - 20 °C / Inert atmosphere

With dmap; 2-picoline borane complex; water; acetic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; toluene; 2.1: Yamaguchi reaction / 4.1: Yamaguchi reaction;
DOI:10.1016/j.tet.2011.08.014

Reference yield:

: 1135051-09-0
(2R,3S)-3-tert-butyldiphenylsilyloxy-4-penten-2-ol

: 1335287-06-3
(S)-2-[(1S,2R)-2-tert-butyldiphenylsilyloxy-1-methyl-3-butenyloxycarbonyl]-1-methylethyl (2E,4R,5S)-5-{N-acryloyl-(E)-[2-methyl-3-(2-methyl-4-thiazolyl)allyl]amino}-4-(2-methoxyethoxy)methoxy-2-hexenoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: dmap / toluene / 1 h / 20 °C / Inert atmosphere

2.1: water; acetic acid / tetrahydrofuran / Inert atmosphere

3.1: dmap / toluene / 1 h / 20 °C / Inert atmosphere

4.1: trifluoroacetic acid / dichloromethane / 0.25 h / 0 °C / Inert atmosphere

4.2: Inert atmosphere; Saturated solution

5.1: 2-picoline borane complex; acetic acid / methanol / 0 - 20 °C / Inert atmosphere

6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 - 20 °C / Inert atmosphere

With dmap; 2-picoline borane complex; water; acetic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; toluene; 1.1: Yamaguchi reaction / 3.1: Yamaguchi reaction;
DOI:10.1016/j.tet.2011.08.014

Reference yield:

: 1335286-57-1
(S)-2-[(1S,2R)-2-tert-butyldiphenylsilyloxy-1-methyl-3-butenyloxycarbonyl]-1-methylethyl (2E,4R,5S)-5-tert-butoxycarbonylamino-4-(2-methoxyethoxy)methoxy-2-hexenoate

: 1335287-06-3
(S)-2-[(1S,2R)-2-tert-butyldiphenylsilyloxy-1-methyl-3-butenyloxycarbonyl]-1-methylethyl (2E,4R,5S)-5-{N-acryloyl-(E)-[2-methyl-3-(2-methyl-4-thiazolyl)allyl]amino}-4-(2-methoxyethoxy)methoxy-2-hexenoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / dichloromethane / 0.25 h / 0 °C / Inert atmosphere

1.2: Inert atmosphere; Saturated solution

2.1: 2-picoline borane complex; acetic acid / methanol / 0 - 20 °C / Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 - 20 °C / Inert atmosphere

With 2-picoline borane complex; acetic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In methanol; dichloromethane;
DOI:10.1016/j.tet.2011.08.014