2,3-Dihydro-7-(phenylmethoxy)-1H-indene-1-spiro-2'-<5',8'-bis(methoxymethoxy)-4',6'-dimethoxy-3'-hydroxy-9'-(phenylmethoxy)-2'H-benzinden-1'-one>

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Chemical Name:2,3-Dihydro-7-(phenylmethoxy)-1H-indene-1-spiro-2'-<5',8'-bis(methoxymethoxy)-4',6'-dimethoxy-3'-hydroxy-9'-(phenylmethoxy)-2'H-benzinden-1'-one>
CAS No.:133099-92-0
Molecular Formula:C₄₁H₄₀O₁₀
Molecular Weight:692.763
Hs Code.:

2,3-Dihydro-7-(phenylmethoxy)-1H-indene-1-spiro-2'-<5',8'-bis(methoxymethoxy)-4',6'-dimethoxy-3'-hydroxy-9'-(phenylmethoxy)-2'H-benz<f>inden-1'-one>

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Chemical Property of 2,3-Dihydro-7-(phenylmethoxy)-1H-indene-1-spiro-2'-<5',8'-bis(methoxymethoxy)-4',6'-dimethoxy-3'-hydroxy-9'-(phenylmethoxy)-2'H-benzinden-1'-one>

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Technology Process of 2,3-Dihydro-7-(phenylmethoxy)-1H-indene-1-spiro-2'-<5',8'-bis(methoxymethoxy)-4',6'-dimethoxy-3'-hydroxy-9'-(phenylmethoxy)-2'H-benzinden-1'-one>

There total 9 articles about 2,3-Dihydro-7-(phenylmethoxy)-1H-indene-1-spiro-2'-<5',8'-bis(methoxymethoxy)-4',6'-dimethoxy-3'-hydroxy-9'-(phenylmethoxy)-2'H-benzinden-1'-one> which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 133099-91-9
5,8-Bis(methoxymethoxy)-4,6-dimethoxy-2-<1-oxo-1-<7'-(phenylmethoxy)-1'-indanyl>methyl>-1-(phenylmethoxy)naphthalene-3-carboxaldehyde

: 133099-92-0,133099-93-1
2,3-Dihydro-7-(phenylmethoxy)-1H-indene-1-spiro-2'-<5',8'-bis(methoxymethoxy)-4',6'-dimethoxy-3'-hydroxy-9'-(phenylmethoxy)-2'H-benzinden-1'-one>

Guidance literature:: With sodium methylate; In methanol; at 65 ℃; for 5.5h;
DOI:10.1021/jo00006a029

Reference yield:

: 133099-89-5,133099-90-8
5,8-Bis(methoxymethoxy)-4,6-dimethoxy-3-(1-hydroxymethyl)-2-<1-hydroxy-1-<7'-(phenylmethoxy)-1'-indanyl>methyl>-1-(phenylmethoxy)naphthalene

: 133099-92-0,133099-93-1
2,3-Dihydro-7-(phenylmethoxy)-1H-indene-1-spiro-2'-<5',8'-bis(methoxymethoxy)-4',6'-dimethoxy-3'-hydroxy-9'-(phenylmethoxy)-2'H-benzinden-1'-one>

Guidance literature:: With oxalyl dichloride; dimethyl sulfoxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; Yield given. Multistep reaction; 1) CH₂Cl₂, -78 deg C, 2 h, 2) -78 deg C to r.t., 5.5 h;
DOI:10.1021/jo00006a029

Reference yield:

: 2973-76-4
5-bromo-4-hydroxy-3-methoxybenzaldehyde

: 133099-92-0,133099-93-1
2,3-Dihydro-7-(phenylmethoxy)-1H-indene-1-spiro-2'-<5',8'-bis(methoxymethoxy)-4',6'-dimethoxy-3'-hydroxy-9'-(phenylmethoxy)-2'H-benzinden-1'-one>

Guidance literature:: Multi-step reaction with 9 steps

1: 1) Bu₄NI, NaH / 1) DMF, 10 min., r.t., 2) r.t., 24 h

2: m-chloroperbenzoic acid / CH₂Cl₂ / 16 h / Ambient temperature

3: 10percent aq.KOH / methanol / 12 h / 25 °C

4: 1) Bu₄NI, NaH / 1) DMF, r.t., 0.5 h, 2) 72 h, 25 deg C

5: 1) n-BuLi, 2) Cr(CO)6

6: 78 percent / K₂CO₃, Bu₄NI / acetone / 64 h / 55 °C

7: 89 percent / n-Bu₄NF / tetrahydrofuran / 14 h / 55 °C

8: 1) (COCl)2, DMSO, 2) Et₃N

9: 82 percent / NaOCH₃ / methanol / 5.5 h / 65 °C

With potassium hydroxide; n-butyllithium; oxalyl dichloride; tetrabutyl ammonium fluoride; sodium methylate; tetra-(n-butyl)ammonium iodide; sodium hydride; potassium carbonate; dimethyl sulfoxide; chromium⁽⁰⁾ hexacarbonyl; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; dichloromethane; acetone;
DOI:10.1021/jo00006a029