Technology Process of rac-(7'ξ,8β,8'α)-7'-hydroxy-3,4,3',4',5'-pentamethoxylignan-9',9-olide
There total 3 articles about rac-(7'ξ,8β,8'α)-7'-hydroxy-3,4,3',4',5'-pentamethoxylignan-9',9-olide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 99 percent / 10percent Pd/C, H2 / ethyl acetate
2: 1.) potassium hydroxide, 2.) sodium borohydride, calcium chloride / 1.) ethanol, 2.) ethanol, a.) -23 deg C, 1 h, b.) room temp., overnight
3: 1.) litium diisopropylamide / 1.) THF, -78 deg C, 30 min., 2.) -23 deg C, 1 h
With
potassium hydroxide; sodium tetrahydroborate; palladium on activated charcoal; hydrogen; calcium chloride; lithium diisopropyl amide;
In
ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 55 percent / sodium methoxide / methanol / 1.) 30 min., reflux, 2.) room temp., overnight
2: 99 percent / 10percent Pd/C, H2 / ethyl acetate
3: 1.) potassium hydroxide, 2.) sodium borohydride, calcium chloride / 1.) ethanol, 2.) ethanol, a.) -23 deg C, 1 h, b.) room temp., overnight
4: 1.) litium diisopropylamide / 1.) THF, -78 deg C, 30 min., 2.) -23 deg C, 1 h
With
potassium hydroxide; sodium tetrahydroborate; palladium on activated charcoal; hydrogen; sodium methylate; calcium chloride; lithium diisopropyl amide;
In
methanol; ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 1.) potassium hydroxide, 2.) sodium borohydride, calcium chloride / 1.) ethanol, 2.) ethanol, a.) -23 deg C, 1 h, b.) room temp., overnight
2: 1.) litium diisopropylamide / 1.) THF, -78 deg C, 30 min., 2.) -23 deg C, 1 h
With
potassium hydroxide; sodium tetrahydroborate; calcium chloride; lithium diisopropyl amide;
