N-<4-methyl>-N-prop-2-ynylamino>benzoyl>-L-glutamic acid trifluoroacetate

Base Information

Chemical Name:N-<4-methyl>-N-prop-2-ynylamino>benzoyl>-L-glutamic acid trifluoroacetate
CAS No.:130379-79-2
Molecular Formula:C₂HF₃O₂*C₂₅H₂₃FN₄O₆
Molecular Weight:608.503
Hs Code.:

N-<4-<N-<<3,4-dihydro-2-(fluoromethyl)-4-oxo-6-quinazolinyl>methyl>-N-prop-2-ynylamino>benzoyl>-L-glutamic acid trifluoroacetate

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Chemical Property of N-<4-methyl>-N-prop-2-ynylamino>benzoyl>-L-glutamic acid trifluoroacetate

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Technology Process of N-<4-methyl>-N-prop-2-ynylamino>benzoyl>-L-glutamic acid trifluoroacetate

There total 4 articles about N-<4-methyl>-N-prop-2-ynylamino>benzoyl>-L-glutamic acid trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 112888-48-9
(S)-2-{4-[(2-Fluoromethyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-pentanedioic acid di-tert-butyl ester

: 76-05-1
trifluoroacetic acid

: 130379-79-2
N-<4-methyl>-N-prop-2-ynylamino>benzoyl>-L-glutamic acid trifluoroacetate

Guidance literature:: In chloroform; for 4h; Ambient temperature;
DOI:10.1021/jm00173a024

Reference yield:

: 2941-78-8
2-Amino-5-methylbenzoic acid

: 130379-79-2
N-<4-methyl>-N-prop-2-ynylamino>benzoyl>-L-glutamic acid trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaOEt / 1.) ethanol, RT, 45 min, 2.) 60 h

2: N-bromosuccinimide (NBS), benzoyl peroxide / CCl₄ / 8 h / Heating; Irradiation

3: 37 percent / 2,6-lutidine / dimethylformamide / 18 h / 60 °C

4: 56 percent / CHCl₃ / 4 h / Ambient temperature

With 2,6-dimethylpyridine; N-Bromosuccinimide; Perbenzoic acid; sodium ethanolate; In tetrachloromethane; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm00173a024

Reference yield:

: 112888-49-0
2-fluoromethyl-3,4-dihydro-6-methylquinazolin-4-one

: 130379-79-2
N-<4-methyl>-N-prop-2-ynylamino>benzoyl>-L-glutamic acid trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1: N-bromosuccinimide (NBS), benzoyl peroxide / CCl₄ / 8 h / Heating; Irradiation

2: 37 percent / 2,6-lutidine / dimethylformamide / 18 h / 60 °C

3: 56 percent / CHCl₃ / 4 h / Ambient temperature

With 2,6-dimethylpyridine; N-Bromosuccinimide; Perbenzoic acid; In tetrachloromethane; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm00173a024