1-[(2-chloro-5-thiazolyl)methyl]-3-[3-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]phenyl]-2-hydroxy-9-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidinium inner salt

Base Information

Chemical Name:1-[(2-chloro-5-thiazolyl)methyl]-3-[3-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]phenyl]-2-hydroxy-9-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidinium inner salt
CAS No.:1391815-52-3
Molecular Formula:C₂₅H₁₅Cl₂F₃N₄O₂S
Molecular Weight:563.387
Hs Code.:

1-[(2-chloro-5-thiazolyl)methyl]-3-[3-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]phenyl]-2-hydroxy-9-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidinium inner salt

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Chemical Property of 1-[(2-chloro-5-thiazolyl)methyl]-3-[3-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]phenyl]-2-hydroxy-9-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidinium inner salt

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Technology Process of 1-[(2-chloro-5-thiazolyl)methyl]-3-[3-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]phenyl]-2-hydroxy-9-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidinium inner salt

There total 3 articles about 1-[(2-chloro-5-thiazolyl)methyl]-3-[3-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]phenyl]-2-hydroxy-9-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidinium inner salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 56911-48-9
diethyl (3-bromophenyl)malonate

: 1391815-52-3
1-[(2-chloro-5-thiazolyl)methyl]-3-[3-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]phenyl]-2-hydroxy-9-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidinium inner salt

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 3 h / Reflux

2.1: potassium carbonate / bis(triphenylphosphine)palladium(II) dichloride / water; tetrahydrofuran / 3 h / Inert atmosphere; Reflux

3.1: sodium hydroxide; water / 1 h / 50 °C

3.2: 1 h

3.3: 0.17 h / Cooling with acetone-dry ice

With water; potassium acetate; potassium carbonate; sodium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; bis(triphenylphosphine)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; water;

Reference yield:

: 1391815-59-0
1,3-diethyl 2-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]propanedioate

: 1391815-52-3
1-[(2-chloro-5-thiazolyl)methyl]-3-[3-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]phenyl]-2-hydroxy-9-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidinium inner salt

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / bis(triphenylphosphine)palladium(II) dichloride / water; tetrahydrofuran / 3 h / Inert atmosphere; Reflux

2.1: sodium hydroxide; water / 1 h / 50 °C

2.2: 1 h

2.3: 0.17 h / Cooling with acetone-dry ice

With water; potassium carbonate; sodium hydroxide; bis(triphenylphosphine)palladium(II) dichloride; In tetrahydrofuran; water;

Reference yield:

: 1603-40-3
3-methylpyridin-2-ylamine

: 1391815-52-3
1-[(2-chloro-5-thiazolyl)methyl]-3-[3-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]phenyl]-2-hydroxy-9-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidinium inner salt

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic anhydride / ethyl acetate / 0.58 h / 45 - 46 °C / Inert atmosphere

1.2: 7 h / 20 - 48 °C

2.1: potassium carbonate; tetrabutylammomium bromide / isopropyl alcohol / 5.5 h / 73 - 75 °C / Inert atmosphere

2.2: 3.83 h / 50 - 60 °C

3.1: sodium hydroxide; water / 1 h / 50 °C

3.2: 1 h

3.3: 0.17 h / Cooling with acetone-dry ice

With tetrabutylammomium bromide; water; acetic anhydride; potassium carbonate; sodium hydroxide; In ethyl acetate; isopropyl alcohol;