(E)-3-(2,5-Dimethoxy-phenyl)-2-phenyl-acrylonitrile

Base Information

• Chemical Name: (E)-3-(2,5-Dimethoxy-phenyl)-2-phenyl-acrylonitrile
• CAS No.: 80654-48-4
• Molecular Formula: C₁₇H₁₅NO₂
• Molecular Weight: 265.312
• Mol file: 80654-48-4.mol

Synonyms:

Chemical Property of (E)-3-(2,5-Dimethoxy-phenyl)-2-phenyl-acrylonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-3-(2,5-Dimethoxy-phenyl)-2-phenyl-acrylonitrile

There total 2 articles about (E)-3-(2,5-Dimethoxy-phenyl)-2-phenyl-acrylonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,4-dimethoxybezene (150-78-7) → 3-(2,5-dimethoxy-phenyl)-2-phenyl-acrylonitrile (80654-48-4)

Guidance literature:

Multi-step reaction with 2 steps

1: benzene; AlCl₃ / man erhitzt dann auf 35-40grad und leitet 4 Stdn_. HCl durch die Fluessigkeit; man zersetzt das Reaktionsprodukt erst mit Eiswasser, dann durch Destillation mit Wasserdampf

2: alcohol; NaOH-solution

With sodium hydroxide; aluminium trichloride; ethanol; benzene;

DOI:10.1093/pa/53.3.605

Reference yield:

→ 3-(2,5-dimethoxy-phenyl)-2-phenyl-acrylonitrile (80654-48-4)

Guidance literature:

Phenylacetonitril u. 2,5-Dimethyl-benzaldehyd in A. bei 70grad;

DOI:10.1039/j39690002069

Reference yield: 90.0%

(E)-3-(2,5-Dimethoxy-phenyl)-2-phenyl-acrylonitrile (42172-52-1,80654-48-4) → 3-(2,5-Dimethoxy-phenyl)-2-phenyl-propionitrile (80654-49-5)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; for 2.5h; under 1838.8 Torr;

upstream raw materials:

1,4-dimethoxybezene

Downstream raw materials:

3-(2,5-Dimethoxy-phenyl)-2-phenyl-propionitrile

3-(2,5-Dimethoxy-phenyl)-2-phenyl-propylamine

2-[3-(2,5-Dimethoxy-phenyl)-2-phenyl-propylamino]-1-phenyl-ethanol