2-(3-Chloro-4-methoxyphenyl)-2-hydroxypropanoic acid

Base Information

Chemical Name:2-(3-Chloro-4-methoxyphenyl)-2-hydroxypropanoic acid
CAS No.:91121-62-9
Molecular Formula:C₁₀H₁₁ClO₄
Molecular Weight:230.648
Hs Code.:
DSSTox Substance ID:DTXSID601203702

Synonyms:2-(3-chloro-4-methoxyphenyl)-2-hydroxypropanoic acid;DTXSID601203702;AKOS022347537;3-Chloro-alpha-hydroxy-4-methoxy-alpha-methylbenzeneacetic acid;91121-62-9

Suppliers and Price of 2-(3-Chloro-4-methoxyphenyl)-2-hydroxypropanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(3-Chloro-4-methoxyphenyl)-2-hydroxypropanoic acid

Chemical Property:

XLogP3:1.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:230.0345865
Heavy Atom Count:15
Complexity:246

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C1=CC(=C(C=C1)OC)Cl)(C(=O)O)O

Technology Process of 2-(3-Chloro-4-methoxyphenyl)-2-hydroxypropanoic acid

There total 3 articles about 2-(3-Chloro-4-methoxyphenyl)-2-hydroxypropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 70154-91-5
ethyl 2-(3-chloro-4-methoxyphenyl)-2-hydroxypropanoate

: 91121-62-9
2-(3-chloro-4-methoxyphenyl)-2-hydroxypropanoic acid

Guidance literature:: With water; potassium carbonate; In ethanol; for 4h; Yield given; Heating;
DOI:10.1135/cccc19840122

Reference yield:

: 766-51-8
2-Chloroanisole

: 91121-62-9
2-(3-chloro-4-methoxyphenyl)-2-hydroxypropanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 56.2 percent / AlCl₃ / 1,2-dichloro-ethane / 1) addition of AlCl₃ at temperature not exceeding 15 deg C 2) 10 deg C, 1 h 3) 20 deg C, 4 h

2: Mg / 1) ether, 0 deg C, 4 h 2) 20 deg C, 3 h

3: K₂CO₃, H₂O / aq. ethanol / 4 h / Heating

With aluminium trichloride; water; potassium carbonate; magnesium; In ethanol; 1,2-dichloro-ethane;
DOI:10.1135/cccc19840122

Reference yield:

: 70154-90-4
ethyl (3-chloro-4-methoxyphenyl)glyoxylate

: 91121-62-9
2-(3-chloro-4-methoxyphenyl)-2-hydroxypropanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: Mg / 1) ether, 0 deg C, 4 h 2) 20 deg C, 3 h

2: K₂CO₃, H₂O / aq. ethanol / 4 h / Heating

With water; potassium carbonate; magnesium; In ethanol;
DOI:10.1135/cccc19840122