Methyl 3-(2-phenoxybenzyl)-2,3,4,4a,5,6-hexahydro-1H-pyrazino[1,2-a]quinoline-8-carboxylate

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Chemical Name:Methyl 3-(2-phenoxybenzyl)-2,3,4,4a,5,6-hexahydro-1H-pyrazino[1,2-a]quinoline-8-carboxylate
CAS No.:1053266-42-4
Molecular Formula:C₂₇H₂₈N₂O₃
Molecular Weight:428.531
Hs Code.:

Synonyms:

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Chemical Property of Methyl 3-(2-phenoxybenzyl)-2,3,4,4a,5,6-hexahydro-1H-pyrazino[1,2-a]quinoline-8-carboxylate

Chemical Property:

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Technology Process of Methyl 3-(2-phenoxybenzyl)-2,3,4,4a,5,6-hexahydro-1H-pyrazino[1,2-a]quinoline-8-carboxylate

There total 10 articles about Methyl 3-(2-phenoxybenzyl)-2,3,4,4a,5,6-hexahydro-1H-pyrazino[1,2-a]quinoline-8-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1053265-02-3
methyl (4aS,R)-2,3,4,4a,5,6-hexahydro-1H-pyrazino[1,2-a]quinoline-8-carboxylate

: 19434-34-5
2-(phenoxy)benzaldehyde

: 1053266-42-4
Methyl 3-(2-phenoxybenzyl)-2,3,4,4a,5,6-hexahydro-1H-pyrazino[1,2-a]quinoline-8-carboxylate

Guidance literature:: methyl (4aS,R)-2,3,4,4a,5,6-hexahydro-1H-pyrazino[1,2-a]quinoline-8-carboxylate; 2-(phenoxy)benzaldehyde; With sodium tris(acetoxy)borohydride;

With acetic acid;

Reference yield:

: 478407-26-0
2-{[(6-Methoxy-2-quinolyl)methyl]amino}ethanol

: 1053266-42-4
Methyl 3-(2-phenoxybenzyl)-2,3,4,4a,5,6-hexahydro-1H-pyrazino[1,2-a]quinoline-8-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium hydroxide / nickel / methanol; water / 20 °C

2.1: phosphorus pentoxide / o-xylene / 150 °C

3.1: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 2 h / 80 °C

4.1: boron tribromide / dichloromethane / 0 - 20 °C

4.2: 0.5 h / 0 - 20 °C

5.1: triethylamine / dichloromethane

6.1: triethylamine / 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate / dimethyl sulfoxide / 3.75 h / 65 °C

7.1: ammonium formate / palladium 10% on activated carbon / tetrahydrofuran; methanol / 4 h / 50 °C

8.1: sodium tris(acetoxy)borohydride

With potassium hydroxide; ammonium formate; phosphorus pentoxide; boron tribromide; sodium tris(acetoxy)borohydride; potassium carbonate; triethylamine; sodium iodide; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; palladium 10% on activated carbon; nickel; In tetrahydrofuran; methanol; dichloromethane; o-xylene; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 21535-74-0
(4aS,R)-8-methoxy-2,3,4,4a,5,6-hexahydro-1H-pyrazino[1,2-a]quinoline

: 1053266-42-4
Methyl 3-(2-phenoxybenzyl)-2,3,4,4a,5,6-hexahydro-1H-pyrazino[1,2-a]quinoline-8-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 2 h / 80 °C

2.1: boron tribromide / dichloromethane / 0 - 20 °C

2.2: 0.5 h / 0 - 20 °C

3.1: triethylamine / dichloromethane

4.1: triethylamine / 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate / dimethyl sulfoxide / 3.75 h / 65 °C

5.1: ammonium formate / palladium 10% on activated carbon / tetrahydrofuran; methanol / 4 h / 50 °C

6.1: sodium tris(acetoxy)borohydride

With ammonium formate; boron tribromide; sodium tris(acetoxy)borohydride; potassium carbonate; triethylamine; sodium iodide; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;