Technology Process of (3E,5E)-2-Hydroxy-3-methyl-6-phenyl-hexa-3,5-dienoic acid methyl ester
There total 4 articles about (3E,5E)-2-Hydroxy-3-methyl-6-phenyl-hexa-3,5-dienoic acid methyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: MnO2 / CH2Cl2 / 3 h / Ambient temperature
2: 2.)HgCl2, HgO / 1.)THF, -70 deg C; 2.)MeOH; H2O, room temp., 15 min
With
manganese(IV) oxide; mercury dichloride; mercury(II) oxide;
In
dichloromethane;
DOI:10.1016/S0040-4039(00)95760-5
- Guidance literature:
-
Multi-step reaction with 3 steps
1: LiAlH4 / diethyl ether / 1 h / 0 °C
2: MnO2 / CH2Cl2 / 3 h / Ambient temperature
3: 2.)HgCl2, HgO / 1.)THF, -70 deg C; 2.)MeOH; H2O, room temp., 15 min
With
manganese(IV) oxide; lithium aluminium tetrahydride; mercury dichloride; mercury(II) oxide;
In
diethyl ether; dichloromethane;
DOI:10.1016/S0040-4039(00)95760-5
- Guidance literature:
-
Multi-step reaction with 4 steps
1: tBuO(-)*K(+) / diethyl ether / Ambient temperature
2: LiAlH4 / diethyl ether / 1 h / 0 °C
3: MnO2 / CH2Cl2 / 3 h / Ambient temperature
4: 2.)HgCl2, HgO / 1.)THF, -70 deg C; 2.)MeOH; H2O, room temp., 15 min
With
manganese(IV) oxide; lithium aluminium tetrahydride; potassium tert-butylate; mercury dichloride; mercury(II) oxide;
In
diethyl ether; dichloromethane;
DOI:10.1016/S0040-4039(00)95760-5
