1-p-bromophenyl-1,4-dihydro-4-thioxo-4,6-diphenyl-3-ethoxycarbonyl-1,2,4-diazaphosphorine

Base Information

• Chemical Name: 1-p-bromophenyl-1,4-dihydro-4-thioxo-4,6-diphenyl-3-ethoxycarbonyl-1,2,4-diazaphosphorine
• CAS No.: 128465-12-3
• Molecular Formula: C₂₄H₂₀BrN₂O₂PS
• Molecular Weight: 511.379
• Mol file: 128465-12-3.mol

Synonyms:

Chemical Property of 1-p-bromophenyl-1,4-dihydro-4-thioxo-4,6-diphenyl-3-ethoxycarbonyl-1,2,4-diazaphosphorine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-p-bromophenyl-1,4-dihydro-4-thioxo-4,6-diphenyl-3-ethoxycarbonyl-1,2,4-diazaphosphorine

There total 7 articles about 1-p-bromophenyl-1,4-dihydro-4-thioxo-4,6-diphenyl-3-ethoxycarbonyl-1,2,4-diazaphosphorine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

ethyl (2-chloro-2-phenylvinyl)phenylphosphinothioite (128590-85-2) + ethoxycarbonylformyl chloride p-bromophenylhydrazone (27143-10-8) → 1-p-bromophenyl-1,4-dihydro-4-thioxo-4,6-diphenyl-3-ethoxycarbonyl-1,2,4-diazaphosphorine (128465-12-3)

Guidance literature:

With triethylamine; In benzene; 1.) 4 h, reflux 2.) 24 h, 20 deg C;

Reference yield: 55.0%

S-ethyl phenyl(2-phenylethynyl)thiophosphinite (128465-23-6) + ethoxycarbonylformyl chloride p-bromophenylhydrazone (27143-10-8) → 1-p-bromophenyl-1,4-dihydro-4-thioxo-4,6-diphenyl-3-ethoxycarbonyl-1,2,4-diazaphosphorine (128465-12-3)

Guidance literature:

With triethylamine; In benzene; for 4.5h; Heating;

Reference yield:

ethyl phenylphosphonochloridothioite (23588-02-5) → 1-p-bromophenyl-1,4-dihydro-4-thioxo-4,6-diphenyl-3-ethoxycarbonyl-1,2,4-diazaphosphorine (128465-12-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) Mg / 1) THF, 2) THF, -55 deg C to 20 deg C

2: 55 percent / Et₃N / benzene / 4.5 h / Heating

With magnesium; triethylamine; In benzene;

upstream raw materials:

ethyl (2-chloro-2-phenylvinyl)phenylphosphinothioite

ethoxycarbonylformyl chloride p-bromophenylhydrazone

S-ethyl phenyl(2-phenylethynyl)thiophosphinite

ethyl phenylphosphonochloridothioite

Refernces

• 1、 Namestnikov, V. I.,Trishin, Yu. G.,Tamm, L. A.,Chistokletov, V. N.. "INTERACTION OF THIOESTERS OF ALKYNYLPHOSPHINOUS AND ALKYNYLPHOSPHONOUS ACIDS WITH NITRILIMINES". . p. 444 - 450. Retrieved 2007/10/02.