(3S)-4-cyclohexyl-2-hydroxy-3-<<(2S)-2-<<(2S)-2-(1-oxo-1,3-dihydroisoindol-2-yl)-3-phenylpropionyl>amino>hexanoyl>amino>butyric acid isopropyl ester

Base Information

Chemical Name:(3S)-4-cyclohexyl-2-hydroxy-3-<<(2S)-2-<<(2S)-2-(1-oxo-1,3-dihydroisoindol-2-yl)-3-phenylpropionyl>amino>hexanoyl>amino>butyric acid isopropyl ester
CAS No.:137282-01-0
Molecular Formula:C₃₆H₄₉N₃O₆
Molecular Weight:619.802
Hs Code.:

(3S)-4-cyclohexyl-2-hydroxy-3-<<(2S)-2-<<(2S)-2-(1-oxo-1,3-dihydroisoindol-2-yl)-3-phenylpropionyl>amino>hexanoyl>amino>butyric acid isopropyl ester

Synonyms:

Suppliers and Price of (3S)-4-cyclohexyl-2-hydroxy-3-<<(2S)-2-<<(2S)-2-(1-oxo-1,3-dihydroisoindol-2-yl)-3-phenylpropionyl>amino>hexanoyl>amino>butyric acid isopropyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3S)-4-cyclohexyl-2-hydroxy-3-<<(2S)-2-<<(2S)-2-(1-oxo-1,3-dihydroisoindol-2-yl)-3-phenylpropionyl>amino>hexanoyl>amino>butyric acid isopropyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3S)-4-cyclohexyl-2-hydroxy-3-<<(2S)-2-<<(2S)-2-(1-oxo-1,3-dihydroisoindol-2-yl)-3-phenylpropionyl>amino>hexanoyl>amino>butyric acid isopropyl ester

There total 3 articles about (3S)-4-cyclohexyl-2-hydroxy-3-<<(2S)-2-<<(2S)-2-(1-oxo-1,3-dihydroisoindol-2-yl)-3-phenylpropionyl>amino>hexanoyl>amino>butyric acid isopropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 63-91-2,25191-15-5,658-69-5,67675-33-6
L-phenylalanine

: 137282-01-0,139236-15-0,139238-65-6
(3S)-4-cyclohexyl-2-hydroxy-3-<<(2S)-2-<<(2S)-2-(1-oxo-1,3-dihydroisoindol-2-yl)-3-phenylpropionyl>amino>hexanoyl>amino>butyric acid isopropyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 2.) NaCNBH₃ / 1.) MeOH, 5 min, 2.) MeOH, reflux, overnight

2: 1.) 1-hydroxybenzotriazole (HOBt), 2.) 1-cyclohexyl-3-(2-morpholinoethyl)carbodiimide metho-p-toluenesulfonate (CMC) / 1.) CH₂Cl₂, 0 deg C, 10 min, 2.) CH₂Cl₂, RT, overnight

With N-cyclohexyl-N'-β-(4-methylmorpholinium)ethylcarbodiimide p-toluenesulfonate; sodium cyanoborohydride; benzotriazol-1-ol;
DOI:10.1021/jm00083a005

Reference yield:

: 4122-56-9
methyl o-formylbenzoate

: 137282-01-0,139236-15-0,139238-65-6
(3S)-4-cyclohexyl-2-hydroxy-3-<<(2S)-2-<<(2S)-2-(1-oxo-1,3-dihydroisoindol-2-yl)-3-phenylpropionyl>amino>hexanoyl>amino>butyric acid isopropyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 2.) NaCNBH₃ / 1.) MeOH, 5 min, 2.) MeOH, reflux, overnight

2: 1.) 1-hydroxybenzotriazole (HOBt), 2.) 1-cyclohexyl-3-(2-morpholinoethyl)carbodiimide metho-p-toluenesulfonate (CMC) / 1.) CH₂Cl₂, 0 deg C, 10 min, 2.) CH₂Cl₂, RT, overnight

With N-cyclohexyl-N'-β-(4-methylmorpholinium)ethylcarbodiimide p-toluenesulfonate; sodium cyanoborohydride; benzotriazol-1-ol;
DOI:10.1021/jm00083a005

Reference yield:

: 105776-76-9
(S)-2-(1-oxo-1,3-dihydroisoindol-2-yl)-3-phenylpropionic acid

: 137331-81-8
(S)-3-((S)-2-Amino-hexanoylamino)-4-cyclohexyl-2-hydroxy-butyric acid isopropyl ester; compound with trifluoro-acetic acid

: 137282-01-0,139236-15-0,139238-65-6
(3S)-4-cyclohexyl-2-hydroxy-3-<<(2S)-2-<<(2S)-2-(1-oxo-1,3-dihydroisoindol-2-yl)-3-phenylpropionyl>amino>hexanoyl>amino>butyric acid isopropyl ester

Guidance literature:: With N-cyclohexyl-N'-β-(4-methylmorpholinium)ethylcarbodiimide p-toluenesulfonate; benzotriazol-1-ol; Yield given. Multistep reaction; 1.) CH₂Cl₂, 0 deg C, 10 min, 2.) CH₂Cl₂, RT, overnight;
DOI:10.1021/jm00083a005